Autor segons l'article: Vallvé JC; Serra N; Zalba G; Fortuño A; Beloqui O; Ferre R; Ribalta J; Masana L
Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/s de la URV: FERRÉ VALLÈS, RAIMON / Masana Marín, Luis / Ribalta Vives, Josep / Serra Encinas, Noemi / Vallvé Torrente, Joan Carles
Resum: Arterial stiffness is an important factor in hypertension. Fibulin 2 is an extracellular matrix scaffold protein involved in arterial stiffness and, hence, the fibulin 2 (FBLN2) gene may be a candidate for hypertension susceptibility. 4 single nucleotide polymorphisms (SNPs) of FBLN2 were evaluated in an association case-control study containing 447 hypertensive patients and 344 normotensive control subjects. The minor allele frequencies of rs3732666 and rs1061376 were significantly lower in hypertensives. The odds ratios (OR) for having the protective G (rs3732666) and T (rs1061376) alleles were 0.75 (95%CI: 0.58 to 0.96) and 0.83 (95%CI: 0.66 to 1.02), respectively. For rs3732666, the OR for hypertension in AG+GG subjects, compared with AA, was 0.71 (95%CI: 0.52 to 0.95). The protective genotype AG+GG was associated with significantly lower systolic blood pressure (SBP) [-3.6 mmHg (P = 0.048)]. There was a significant age interaction with rs3732666; the effect decreasing with increasing age. For rs1061376, TT subjects had an OR for hypertension of 0.53 (95%CI: 0.32 to 0.87) compared with CC subjects, with reduced SBP (-7.91 mmHg; P = 0.008) and diastolic BP (DBP) (-3.69 mmHg; P = 0.015). The presence of a G allele was an independent predictor of intima-media thickness (IMT); G carrier's having lower mean IMT (-0.037 mm, P = 0.027) compared with AA. Our results provide the first evidence for FBLN2 as a new gene associated with hypertension. © 2012 Vallvé et al.
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Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Adreça de correu electrònic de l'autor: jc.vallve@urv.cat josep.ribalta@urv.cat luis.masana@urv.cat jc.vallve@urv.cat noemi.serra@urv.cat
Identificador de l'autor: 0000-0002-8879-4719 0000-0002-0789-4954 0000-0002-2277-351X
Data d'alta del registre: 2024-05-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043051
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Plos One. 7 (8): e43051-
Referència de l'ítem segons les normes APA: Vallvé JC; Serra N; Zalba G; Fortuño A; Beloqui O; Ferre R; Ribalta J; Masana L (2012). Two variants in the Fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension. Plos One, 7(8), e43051-. DOI: 10.1371/journal.pone.0043051
DOI de l'article: 10.1371/journal.pone.0043051
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2012
Tipus de publicació: Journal Publications
Repositori URV