Autor según el artículo: Vallvé JC; Serra N; Zalba G; Fortuño A; Beloqui O; Ferre R; Ribalta J; Masana L
Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: FERRÉ VALLÈS, RAIMON / Masana Marín, Luis / Ribalta Vives, Josep / Serra Encinas, Noemi / Vallvé Torrente, Joan Carles
Resumen: Arterial stiffness is an important factor in hypertension. Fibulin 2 is an extracellular matrix scaffold protein involved in arterial stiffness and, hence, the fibulin 2 (FBLN2) gene may be a candidate for hypertension susceptibility. 4 single nucleotide polymorphisms (SNPs) of FBLN2 were evaluated in an association case-control study containing 447 hypertensive patients and 344 normotensive control subjects. The minor allele frequencies of rs3732666 and rs1061376 were significantly lower in hypertensives. The odds ratios (OR) for having the protective G (rs3732666) and T (rs1061376) alleles were 0.75 (95%CI: 0.58 to 0.96) and 0.83 (95%CI: 0.66 to 1.02), respectively. For rs3732666, the OR for hypertension in AG+GG subjects, compared with AA, was 0.71 (95%CI: 0.52 to 0.95). The protective genotype AG+GG was associated with significantly lower systolic blood pressure (SBP) [-3.6 mmHg (P = 0.048)]. There was a significant age interaction with rs3732666; the effect decreasing with increasing age. For rs1061376, TT subjects had an OR for hypertension of 0.53 (95%CI: 0.32 to 0.87) compared with CC subjects, with reduced SBP (-7.91 mmHg; P = 0.008) and diastolic BP (DBP) (-3.69 mmHg; P = 0.015). The presence of a G allele was an independent predictor of intima-media thickness (IMT); G carrier's having lower mean IMT (-0.037 mm, P = 0.027) compared with AA. Our results provide the first evidence for FBLN2 as a new gene associated with hypertension. © 2012 Vallvé et al.
Áreas temáticas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Direcció de correo del autor: jc.vallve@urv.cat josep.ribalta@urv.cat luis.masana@urv.cat jc.vallve@urv.cat noemi.serra@urv.cat
Identificador del autor: 0000-0002-8879-4719 0000-0002-0789-4954 0000-0002-2277-351X
Fecha de alta del registro: 2024-05-27
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043051
Referencia al articulo segun fuente origial: Plos One. 7 (8): e43051-
Referencia de l'ítem segons les normes APA: Vallvé JC; Serra N; Zalba G; Fortuño A; Beloqui O; Ferre R; Ribalta J; Masana L (2012). Two variants in the Fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension. Plos One, 7(8), e43051-. DOI: 10.1371/journal.pone.0043051
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1371/journal.pone.0043051
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2012
Tipo de publicación: Journal Publications
Repositori URV