Articles producció científica> Medicina i Cirurgia

Effects of macro- versus nanoporous silicon substrates on human aortic endothelial cell behavior

  • Dades identificatives

    Identificador: imarina:6388009
    Autors:
    Formentin, PilarAlba, MariaCatalan, UrsulaFernandez-Castillejo, SaraPallares, JosepSola, RosaMarsal, Lluis F
    Resum:
    © 2014, Formentín et al.; licensee Springer. Human aortic endothelial cells play a key role in the pathogenesis of atherosclerosis, which is a common, progressive, and multifactorial disease that is the clinical endpoint of an inflammatory process and endothelial dysfunction. Study and development of new therapies against cardiovascular disease must be tested in vitro cell models, prior to be evaluated in vivo. To this aim, new cell culture platforms are developed that allow cells to grow and respond to their environment in a realistic manner. In this work, the cell adhesion and morphology of endothelial cells are investigated on functionalized porous silicon substrates with two different pore size configurations: macroporous and nanoporous silicon. Herein, we modified the surfaces of porous silicon substrates by aminopropyl triethoxysilane, and we studied how different pore geometries induced different cellular response in the cell morphology and adhesion. The cell growth over the surface of porous silicon becomes an attractive field, especially for medical applications. Surface properties of the biomaterial are associated with cell adhesion and as well as, with proliferation, migration and differentiation.
  • Altres:

    Autor segons l'article: Formentin, Pilar; Alba, Maria; Catalan, Ursula; Fernandez-Castillejo, Sara; Pallares, Josep; Sola, Rosa; Marsal, Lluis F
    Departament: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
    Autor/s de la URV: ALBA MARTÍN, MARÍA / Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Formentín Vallés, Pilar / Marsal Garví, Luis Francisco / Pallarés Curto, Jorge María / Pallarès Marzal, Josep / Solà Alberich, Rosa Maria
    Paraules clau: Porous silicon Haec Cell morphology Cell adhesion
    Resum: © 2014, Formentín et al.; licensee Springer. Human aortic endothelial cells play a key role in the pathogenesis of atherosclerosis, which is a common, progressive, and multifactorial disease that is the clinical endpoint of an inflammatory process and endothelial dysfunction. Study and development of new therapies against cardiovascular disease must be tested in vitro cell models, prior to be evaluated in vivo. To this aim, new cell culture platforms are developed that allow cells to grow and respond to their environment in a realistic manner. In this work, the cell adhesion and morphology of endothelial cells are investigated on functionalized porous silicon substrates with two different pore size configurations: macroporous and nanoporous silicon. Herein, we modified the surfaces of porous silicon substrates by aminopropyl triethoxysilane, and we studied how different pore geometries induced different cellular response in the cell morphology and adhesion. The cell growth over the surface of porous silicon becomes an attractive field, especially for medical applications. Surface properties of the biomaterial are associated with cell adhesion and as well as, with proliferation, migration and differentiation.
    Àrees temàtiques: Química Physics, applied Nutrição Nanoscience and nanotechnology Nanoscience & nanotechnology Medicina ii Medicina i Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Materiais Interdisciplinar General materials science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Condensed matter physics Ciências biológicas ii Biotecnología Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 19317573
    Adreça de correu electrònic de l'autor: ursula.catalan@urv.cat josep.pallares@urv.cat rosa.sola@urv.cat lluis.marsal@urv.cat jordi.pallares@urv.cat pilar.formentin@urv.cat pilar.formentin@urv.cat
    Identificador de l'autor: 0000-0001-8884-9823 0000-0001-7221-5383 0000-0002-8359-235X 0000-0002-5976-1408 0000-0003-0305-2714
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://nanoscalereslett.springeropen.com/articles/10.1186/1556-276X-9-421
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Nanoscale Research Letters. 9 (1): 421-
    Referència de l'ítem segons les normes APA: Formentin, Pilar; Alba, Maria; Catalan, Ursula; Fernandez-Castillejo, Sara; Pallares, Josep; Sola, Rosa; Marsal, Lluis F (2014). Effects of macro- versus nanoporous silicon substrates on human aortic endothelial cell behavior. Nanoscale Research Letters, 9(1), 421-. DOI: 10.1186/1556-276X-9-421
    DOI de l'article: 10.1186/1556-276X-9-421
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2014
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Condensed Matter Physics,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Nanoscience & Nanotechnology,Nanoscience and Nanotechnology,Physics, Applied
    Porous silicon
    Haec
    Cell morphology
    Cell adhesion
    Química
    Physics, applied
    Nutrição
    Nanoscience and nanotechnology
    Nanoscience & nanotechnology
    Medicina ii
    Medicina i
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    Materiais
    Interdisciplinar
    General materials science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Condensed matter physics
    Ciências biológicas ii
    Biotecnología
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
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