Autor según el artículo: Formentín P; Alba M; Catalán Ú; Fernández-Castillejo S; Pallarès J; Solà R; Marsal L

Departamento: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia

Autor/es de la URV: ALBA MARTÍN, MARÍA / Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Marsal Garví, Luis Francisco / Pallarès Marzal, Josep / Solà Alberich, Rosa Maria

Palabras clave: Porous silicon Haec Cell morphology Cell adhesion

Resumen: © 2014, Formentín et al.; licensee Springer. Human aortic endothelial cells play a key role in the pathogenesis of atherosclerosis, which is a common, progressive, and multifactorial disease that is the clinical endpoint of an inflammatory process and endothelial dysfunction. Study and development of new therapies against cardiovascular disease must be tested in vitro cell models, prior to be evaluated in vivo. To this aim, new cell culture platforms are developed that allow cells to grow and respond to their environment in a realistic manner. In this work, the cell adhesion and morphology of endothelial cells are investigated on functionalized porous silicon substrates with two different pore size configurations: macroporous and nanoporous silicon. Herein, we modified the surfaces of porous silicon substrates by aminopropyl triethoxysilane, and we studied how different pore geometries induced different cellular response in the cell morphology and adhesion. The cell growth over the surface of porous silicon becomes an attractive field, especially for medical applications. Surface properties of the biomaterial are associated with cell adhesion and as well as, with proliferation, migration and differentiation.

Áreas temáticas: Química Physics, applied Nutrição Nanoscience and nanotechnology Nanoscience & nanotechnology Medicina ii Medicina i Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Materiais Interdisciplinar General materials science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Condensed matter physics Ciências biológicas ii Biotecnología Astronomia / física Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19317573

Direcció de correo del autor: ursula.catalan@urv.cat lluis.marsal@urv.cat rosa.sola@urv.cat josep.pallares@urv.cat

Identificador del autor: 0000-0001-8884-9823 0000-0002-5976-1408 0000-0002-8359-235X 0000-0001-7221-5383

Fecha de alta del registro: 2023-04-01

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://nanoscalereslett.springeropen.com/articles/10.1186/1556-276X-9-421

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nanoscale Research Letters. 9 (1): 421-

Referencia de l'ítem segons les normes APA: Formentín P; Alba M; Catalán Ú; Fernández-Castillejo S; Pallarès J; Solà R; Marsal L (2014). Effects of macro- versus nanoporous silicon substrates on human aortic endothelial cell behavior. Nanoscale Research Letters, 9(1), 421-. DOI: 10.1186/1556-276X-9-421

DOI del artículo: 10.1186/1556-276X-9-421

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2014

Tipo de publicación: Journal Publications