Autor segons l'article: Pla-Paga, Laura; Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Foguet-Romero, Elisabet; Catalan, Ursula; Mayneris-Perxachs, Jordi; Canela, Nuria; Valls, Rosa M; Arola, Lluis; Sola, Rosa; Pedret, Anna
Departament: Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/s de la URV: Arola Ferrer, Luis Maria / Catalán Santos, Úrsula / GIBERT RAMOS, ALBERT / Gual Grau, Andreu / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Paraules clau: Stress Rats, sprague-dawley Proteomics Proteins Protein Myocardium Mice Metabolic syndrome Male Kidneys Kidney Hesperidin Heart Family Expression Disease Dietary supplements Diet Cells Cd2ap Blood-pressure Animals metabolic syndrome kidneys hesperidin
Resum: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats. Methods and results: 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg−1 day−1), MS rats without HS, and MS rats administered with HS (100 mg kg−1 day−1) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases. Conclusion: This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.
Àrees temàtiques: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Adreça de correu electrònic de l'autor: ursula.catalan@urv.cat anna.pedret@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Identificador de l'autor: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
Data d'alta del registre: 2024-10-19
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201901063
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Molecular Nutrition & Food Research. 64 (10): e1901063-
Referència de l'ítem segons les normes APA: Pla-Paga, Laura; Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Foguet-Romero, Elisabet; Catalan, Ursula; Mayneris-Perxachs, Jordi; Canela, N (2020). Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation. Molecular Nutrition & Food Research, 64(10), e1901063-. DOI: 10.1002/mnfr.201901063
DOI de l'article: 10.1002/mnfr.201901063
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications
Repositori URV