Author, as appears in the article.: Pla-Paga, Laura; Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Foguet-Romero, Elisabet; Catalan, Ursula; Mayneris-Perxachs, Jordi; Canela, Nuria; Valls, Rosa M; Arola, Lluis; Sola, Rosa; Pedret, Anna
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Arola Ferrer, Luis Maria / Catalán Santos, Úrsula / GIBERT RAMOS, ALBERT / Gual Grau, Andreu / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Keywords: Stress Rats, sprague-dawley Proteomics Proteins Protein Myocardium Mice Metabolic syndrome Male Kidneys Kidney Hesperidin Heart Family Expression Disease Dietary supplements Diet Cells Cd2ap Blood-pressure Animals metabolic syndrome kidneys hesperidin
Abstract: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats. Methods and results: 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg−1 day−1), MS rats without HS, and MS rats administered with HS (100 mg kg−1 day−1) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases. Conclusion: This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Author's mail: ursula.catalan@urv.cat anna.pedret@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Author identifier: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
Record's date: 2024-10-19
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201901063
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 64 (10): e1901063-
APA: Pla-Paga, Laura; Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Foguet-Romero, Elisabet; Catalan, Ursula; Mayneris-Perxachs, Jordi; Canela, N (2020). Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation. Molecular Nutrition & Food Research, 64(10), e1901063-. DOI: 10.1002/mnfr.201901063
Article's DOI: 10.1002/mnfr.201901063
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV