Articles producció científica> Medicina i Cirurgia

Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

  • Datos identificativos

    Identificador: imarina:6390096
    Autores:
    Pla-Paga, LauraGuirro, MariaGual-Grau, AndreuGibert-Ramos, AlbertFoguet-Romero, ElisabetCatalan, UrsulaMayneris-Perxachs, JordiCanela, NuriaValls, Rosa MArola, LluisSola, RosaPedret, Anna
    Resumen:
    © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats. Methods and results: 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg−1 day−1), MS rats without HS, and MS rats administered with HS (100 mg kg−1 day−1) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases. Conclusion: This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.
  • Otros:

    Autor según el artículo: Pla-Paga, Laura; Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Foguet-Romero, Elisabet; Catalan, Ursula; Mayneris-Perxachs, Jordi; Canela, Nuria; Valls, Rosa M; Arola, Lluis; Sola, Rosa; Pedret, Anna
    Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia
    Autor/es de la URV: Arola Ferrer, Luis Maria / Catalán Santos, Úrsula / GIBERT RAMOS, ALBERT / Gual Grau, Andreu / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
    Palabras clave: Stress Rats, sprague-dawley Proteomics Proteins Protein Myocardium Mice Metabolic syndrome Male Kidneys Kidney Hesperidin Heart Family Expression Disease Dietary supplements Diet Cells Cd2ap Blood-pressure Animals metabolic syndrome kidneys hesperidin
    Resumen: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats. Methods and results: 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg−1 day−1), MS rats without HS, and MS rats administered with HS (100 mg kg−1 day−1) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases. Conclusion: This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.
    Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16134125
    Direcció de correo del autor: ursula.catalan@urv.cat anna.pedret@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
    Identificador del autor: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
    Fecha de alta del registro: 2024-10-19
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201901063
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 64 (10): e1901063-
    Referencia de l'ítem segons les normes APA: Pla-Paga, Laura; Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Foguet-Romero, Elisabet; Catalan, Ursula; Mayneris-Perxachs, Jordi; Canela, N (2020). Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation. Molecular Nutrition & Food Research, 64(10), e1901063-. DOI: 10.1002/mnfr.201901063
    DOI del artículo: 10.1002/mnfr.201901063
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biotechnology,Food Science,Food Science & Technology
    Stress
    Rats, sprague-dawley
    Proteomics
    Proteins
    Protein
    Myocardium
    Mice
    Metabolic syndrome
    Male
    Kidneys
    Kidney
    Hesperidin
    Heart
    Family
    Expression
    Disease
    Dietary supplements
    Diet
    Cells
    Cd2ap
    Blood-pressure
    Animals
    metabolic syndrome
    kidneys
    hesperidin
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
  • Documentos:

  • Cerca a google

    Search to google scholar