Autor según el artículo: Pla-Pagà L; Guirro M; Gual-Grau A; Gibert-Ramos A; Foguet-Romero E; Catalán Ú; Mayneris-Perxachs J; Canela N; Valls RM; Arola L; Solà R; Pedret A

Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia

Autor/es de la URV: Arola Ferrer, Luis Maria / Catalán Santos, Úrsula / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria

Palabras clave: Stress Proteomics Protein Mice Metabolic syndrome Kidneys Hesperidin Family Expression Disease Cells Cd2ap Blood-pressure metabolic syndrome kidneys hesperidin

Resumen: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats. Methods and results: 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg−1 day−1), MS rats without HS, and MS rats administered with HS (100 mg kg−1 day−1) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases. Conclusion: This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.

Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16134125

Direcció de correo del autor: ursula.catalan@urv.cat anna.pedret@urv.cat lluis.arola@urv.cat rosa.sola@urv.cat rosamaria.valls@urv.cat

Identificador del autor: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0003-2767-1974 0000-0002-8359-235X 0000-0002-3351-0942

Fecha de alta del registro: 2023-02-26

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201901063

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 64 (10): e1901063-

Referencia de l'ítem segons les normes APA: Pla-Pagà L; Guirro M; Gual-Grau A; Gibert-Ramos A; Foguet-Romero E; Catalán Ú; Mayneris-Perxachs J; Canela N; Valls RM; Arola L; Solà R; Pedret A (2020). Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation. Molecular Nutrition & Food Research, 64(10), e1901063-. DOI: 10.1002/mnfr.201901063

DOI del artículo: 10.1002/mnfr.201901063

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications