Articles producció científica> Ciències Mèdiques Bàsiques

Cumulative dietary risk assessment overarching different regulatory silos using a margin of exposure approach: A case study with three chemical silos

  • Dades identificatives

    Identificador: imarina:6406175
    Autors:
    Sprong CCrépet AMetruccio FBlaznik UAnagnostopoulos CChristodoulou DLJensen BHKennedy MGonzález NRehurkova IRuprich Jte Biesebeek JDVanacker MMoretto Avan Klaveren J
    Resum:
    © 2020 Elsevier Ltd Risk assessment of chemicals occurring in our diet is commonly performed for single chemicals without considering exposure to other chemicals. We performed a case study on risk assessment of combined dietary exposure to chemicals from different regulatory silos, i.e. pesticides (PPRs), persistent organic pollutants (POPs) and food additives (FAs). Chemicals were grouped into the cumulative assessment group (CAG) liver steatosis using a component-based approach. Based on literature, the CAG included 144 PPRs, 49 POPS and 7 FAs for which concentration data were available. For each silo, chronic combined dietary exposure was assessed for adults and children of nine European countries following the most commonly used exposure methodologies in Europe and by using a relative potency factor approach. For risk characterization, a Margin of Exposure (MOE) was calculated. To overarch the risk across silos, a normalised combined margin of exposure (nMOET) approach was proposed. This case study demonstrated that risk assessment of combined exposure to chemicals can be performed within regulatory silos. It also highlighted important differences in the conservatism of exposure scenarios, the derivation of point of departures and the subsequent acceptable MOEs between the silos. To overarch the risk despite these differences, a nMOET approach can be used.
  • Altres:

    Autor segons l'article: Sprong C; Crépet A; Metruccio F; Blaznik U; Anagnostopoulos C; Christodoulou DL; Jensen BH; Kennedy M; González N; Rehurkova I; Ruprich J; te Biesebeek JD; Vanacker M; Moretto A; van Klaveren J
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Gonzalez Paradell, Nieves
    Paraules clau: Pesticides Persistent organic pollutants Pcbs Margin of exposure Food additives Dioxins Dietary exposure Cumulative risk assessment Chemical mixtures persistent organic pollutants margin of exposure food additives dietary exposure cumulative risk assessment chemical mixtures
    Resum: © 2020 Elsevier Ltd Risk assessment of chemicals occurring in our diet is commonly performed for single chemicals without considering exposure to other chemicals. We performed a case study on risk assessment of combined dietary exposure to chemicals from different regulatory silos, i.e. pesticides (PPRs), persistent organic pollutants (POPs) and food additives (FAs). Chemicals were grouped into the cumulative assessment group (CAG) liver steatosis using a component-based approach. Based on literature, the CAG included 144 PPRs, 49 POPS and 7 FAs for which concentration data were available. For each silo, chronic combined dietary exposure was assessed for adults and children of nine European countries following the most commonly used exposure methodologies in Europe and by using a relative potency factor approach. For risk characterization, a Margin of Exposure (MOE) was calculated. To overarch the risk across silos, a normalised combined margin of exposure (nMOET) approach was proposed. This case study demonstrated that risk assessment of combined exposure to chemicals can be performed within regulatory silos. It also highlighted important differences in the conservatism of exposure scenarios, the derivation of point of departures and the subsequent acceptable MOEs between the silos. To overarch the risk despite these differences, a nMOET approach can be used.
    Àrees temàtiques: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: nieves.gonzalez@urv.cat
    Identificador de l'autor: 0000-0003-4134-016X
    Data d'alta del registre: 2023-02-19
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0278691520303069?via%3Dihub
    Referència a l'article segons font original: Food And Chemical Toxicology. 142 (111416): 111416-
    Referència de l'ítem segons les normes APA: Sprong C; Crépet A; Metruccio F; Blaznik U; Anagnostopoulos C; Christodoulou DL; Jensen BH; Kennedy M; González N; Rehurkova I; Ruprich J; te Biesebee (2020). Cumulative dietary risk assessment overarching different regulatory silos using a margin of exposure approach: A case study with three chemical silos. Food And Chemical Toxicology, 142(111416), 111416-. DOI: 10.1016/j.fct.2020.111416
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.fct.2020.111416
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Toxicology
    Pesticides
    Persistent organic pollutants
    Pcbs
    Margin of exposure
    Food additives
    Dioxins
    Dietary exposure
    Cumulative risk assessment
    Chemical mixtures
    persistent organic pollutants
    margin of exposure
    food additives
    dietary exposure
    cumulative risk assessment
    chemical mixtures
    Toxicology
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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