Autor segons l'article: Vogelezang S; Bradfield JP; Ahluwalia TS; Curtin JA; Lakka TA; Grarup N; Scholz M; van der Most PJ; Monnereau C; Stergiakouli E; Heiskala A; Horikoshi M; Fedko IO; Vilor-Tejedor N; Cousminer DL; Standl M; Wang CA; Viikari J; Geller F; Íñiguez C; Pitkänen N; Chesi A; Bacelis J; Yengo L; Torrent M; Ntalla I; Helgeland Ø; Selzam S; Vonk JM; Zafarmand MH; Heude B; Farooqi IS; Alyass A; Beaumont RN; Have CT; Rzehak P; Bilbao JR; Schnurr TM; Barroso I; Bønnelykke K
Departament: Medicina i Cirurgia
Autor/s de la URV: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín
Paraules clau: Young-adults Prostate-specific antigen Pooled analysis Overweight Obesity Mendelian randomization Genome-wide association Genetic-variation Cardiovascular risk Adiposity
Resum: © 2020 Public Library of Science. All rights reserved. The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Genetics (clinical) Genetics & heredity Genetics Filosofia/teologia:subcomissão filosofia Farmacia Engenharias iv Educação física Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Cancer research Biotecnología Biodiversidade Astronomia / física Antropologia / arqueologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: joaquin.escribano@urv.cat ricardo.closa@urv.cat
Identificador de l'autor: 0000-0002-5041-459X 0000-0002-9963-4163
Data d'alta del registre: 2023-02-19
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008718
Referència a l'article segons font original: Plos Genetics. 16 (10): e1008718-
Referència de l'ítem segons les normes APA: Vogelezang S; Bradfield JP; Ahluwalia TS; Curtin JA; Lakka TA; Grarup N; Scholz M; van der Most PJ; Monnereau C; Stergiakouli E; Heiskala A; Horikoshi (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. Plos Genetics, 16(10), e1008718-. DOI: 10.1371/journal.pgen.1008718
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1371/journal.pgen.1008718
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications