Author, as appears in the article.: Vogelezang S; Bradfield JP; Ahluwalia TS; Curtin JA; Lakka TA; Grarup N; Scholz M; van der Most PJ; Monnereau C; Stergiakouli E; Heiskala A; Horikoshi M; Fedko IO; Vilor-Tejedor N; Cousminer DL; Standl M; Wang CA; Viikari J; Geller F; Íñiguez C; Pitkänen N; Chesi A; Bacelis J; Yengo L; Torrent M; Ntalla I; Helgeland Ø; Selzam S; Vonk JM; Zafarmand MH; Heude B; Farooqi IS; Alyass A; Beaumont RN; Have CT; Rzehak P; Bilbao JR; Schnurr TM; Barroso I; Bønnelykke K
Department: Medicina i Cirurgia
URV's Author/s: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín
Keywords: Young-adults Prostate-specific antigen Pooled analysis Overweight Obesity Mendelian randomization Genome-wide association Genetic-variation Cardiovascular risk Adiposity
Abstract: © 2020 Public Library of Science. All rights reserved. The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Genetics (clinical) Genetics & heredity Genetics Filosofia/teologia:subcomissão filosofia Farmacia Engenharias iv Educação física Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Cancer research Biotecnología Biodiversidade Astronomia / física Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: joaquin.escribano@urv.cat ricardo.closa@urv.cat
Author identifier: 0000-0002-5041-459X 0000-0002-9963-4163
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008718
Papper original source: Plos Genetics. 16 (10): e1008718-
APA: Vogelezang S; Bradfield JP; Ahluwalia TS; Curtin JA; Lakka TA; Grarup N; Scholz M; van der Most PJ; Monnereau C; Stergiakouli E; Heiskala A; Horikoshi (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. Plos Genetics, 16(10), e1008718-. DOI: 10.1371/journal.pgen.1008718
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1371/journal.pgen.1008718
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications