Articles producció científicaBioquímica i Biotecnologia

Crown Procyanidin Tetramer: A Procyanidin with an Unusual Cyclic Skeleton with a Potent Protective Effect against Amyloid--Induced Toxicity

  • Dades identificatives

    Identificador:  imarina:9060535
    Handle: https://hdl.handle.net/20.500.11797/imarina9060535
    Autors:  Zeng, Liming; Pons-Mercade, Pere; Richard, Tristan; Krisa, Stephanie; Teissedre, Pierre-Louis; Jourdes, Michael
    Resum:
    The structure of a new procyanidin tetramer, which we call a crown procyanidin tetramer, with an unprecedented macrocyclic structure has been characterized for the first time. Its comprehensive spectroscopic analysis revealed that it is a symmetric procyanidin tetramer composed of four (-)-epicatechin sub-units linked alternatively via 48 or 46 B-type interflavanyl linkages to form the macrocyclic structure. This NMR-characterized carbon skeleton has never been reported before for procyanidins in grape or in wine, neither in the plant kingdom. Surprisingly, the crown procyanidin tetramer appeared to be specifically localized in grape skin, contrasting with the oligomeric and polymeric procyanidins present in seed, skin, and bunch stem. Moreover, this crown procyanidin tetramer showed promising protective effects against amyloid- induced toxicity.

  • Altres:

    Enllaç font original: https://www.mdpi.com/1420-3049/24/10/1915
    Referència de l'ítem segons les normes APA: Zeng, Liming; Pons-Mercade, Pere; Richard, Tristan; Krisa, Stephanie; Teissedre, Pierre-Louis; Jourdes, Michael; (2019). Crown Procyanidin Tetramer: A Procyanidin with an Unusual Cyclic Skeleton with a Potent Protective Effect against Amyloid--Induced Toxicity. Molecules, 24(10), -. DOI: 10.3390/molecules24101915
    Referència a l'article segons font original: Molecules. 24 (10):
    DOI de l'article: 10.3390/molecules24101915
    Any de publicació de la revista: 2019
    Entitat: Universitat Rovira i Virgili
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Data d'alta del registre: 2021-10-10
    Autor/s de la URV: Pons Mercade, Pere
    Departament: Bioquímica i Biotecnologia
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Tipus de publicació: Journal Publications
    Autor segons l'article: Zeng, Liming; Pons-Mercade, Pere; Richard, Tristan; Krisa, Stephanie; Teissedre, Pierre-Louis; Jourdes, Michael;
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Volum de revista: 24
    e-ISSN: 1420-3049
    Àrees temàtiques: Zootecnia / recursos pesqueiros, Saúde coletiva, Química, Psicología, Planejamento urbano e regional / demografia, Physical and theoretical chemistry, Pharmaceutical science, Organic chemistry, Odontología, Nutrição, Molecular medicine, Medicine (miscellaneous), Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Materiais, Matemática / probabilidade e estatística, Interdisciplinar, Geografía, General medicine, Farmacia, Ensino, Engenharias iv, Engenharias iii, Engenharias ii, Engenharias i, Educação física, Economia, Drug discovery, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciências agrárias i, Ciência de alimentos, Ciência da computação, Chemistry, organic, Chemistry, multidisciplinary, Chemistry (miscellaneous), Biotecnología, Biodiversidade, Biochemistry & molecular biology, Astronomia / física, Analytical chemistry
    Adreça de correu electrònic de l'autor: pere.pons@estudiants.urv.cat

  • Paraules clau:

    Resveratrol
    Red wine
    Procyanidin
    Polyphenols
    Plant proanthocyanidins
    Health
    Grape
    Elucidation
    Crown procyanidin
    Condensed tannin
    Biosynthesis
    Analytical Chemistry
    Biochemistry & Molecular Biology
    Chemistry (Miscellaneous)
    Chemistry
    Multidisciplinary
    Organic
    Drug Discovery
    Medicine (Miscellaneous)
    Molecular Medicine
    Organic Chemistry
    Pharmaceutical Science
    Physical and Theoretical Chemistry
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geografía
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física

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