Author, as appears in the article.: Zeng, Liming; Pons-Mercade, Pere; Richard, Tristan; Krisa, Stephanie; Teissedre, Pierre-Louis; Jourdes, Michael;
Department: Bioquímica i Biotecnologia
e-ISSN: 1420-3049
URV's Author/s: Pons Mercade, Pere
Keywords: Resveratrol Red wine Procyanidin Polyphenols Plant proanthocyanidins Health Grape Elucidation Crown procyanidin Condensed tannin Biosynthesis
Abstract: The structure of a new procyanidin tetramer, which we call a crown procyanidin tetramer, with an unprecedented macrocyclic structure has been characterized for the first time. Its comprehensive spectroscopic analysis revealed that it is a symmetric procyanidin tetramer composed of four (-)-epicatechin sub-units linked alternatively via 48 or 46 B-type interflavanyl linkages to form the macrocyclic structure. This NMR-characterized carbon skeleton has never been reported before for procyanidins in grape or in wine, neither in the plant kingdom. Surprisingly, the crown procyanidin tetramer appeared to be specifically localized in grape skin, contrasting with the oligomeric and polymeric procyanidins present in seed, skin, and bunch stem. Moreover, this crown procyanidin tetramer showed promising protective effects against amyloid- induced toxicity.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physical and theoretical chemistry Pharmaceutical science Organic chemistry Odontología Nutrição Molecular medicine Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Economia Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, organic Chemistry, multidisciplinary Chemistry (miscellaneous) Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física Analytical chemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: pere.pons@estudiants.urv.cat
Author identifier: 0000-0001-5120-1468
Record's date: 2021-10-10
Journal volume: 24
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1420-3049/24/10/1915
Papper original source: Molecules. 24 (10):
APA: Zeng, Liming; Pons-Mercade, Pere; Richard, Tristan; Krisa, Stephanie; Teissedre, Pierre-Louis; Jourdes, Michael; (2019). Crown Procyanidin Tetramer: A Procyanidin with an Unusual Cyclic Skeleton with a Potent Protective Effect against Amyloid--Induced Toxicity. Molecules, 24(10), -. DOI: 10.3390/molecules24101915
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3390/molecules24101915
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV