Autor según el artículo: Zeng, Liming; Pons-Mercade, Pere; Richard, Tristan; Krisa, Stephanie; Teissedre, Pierre-Louis; Jourdes, Michael;

Departamento: Bioquímica i Biotecnologia

e-ISSN: 1420-3049

Autor/es de la URV: Pons Mercade, Pere

Palabras clave: Resveratrol Red wine Procyanidin Polyphenols Plant proanthocyanidins Health Grape Elucidation Crown procyanidin Condensed tannin Biosynthesis

Resumen: The structure of a new procyanidin tetramer, which we call a crown procyanidin tetramer, with an unprecedented macrocyclic structure has been characterized for the first time. Its comprehensive spectroscopic analysis revealed that it is a symmetric procyanidin tetramer composed of four (-)-epicatechin sub-units linked alternatively via 48 or 46 B-type interflavanyl linkages to form the macrocyclic structure. This NMR-characterized carbon skeleton has never been reported before for procyanidins in grape or in wine, neither in the plant kingdom. Surprisingly, the crown procyanidin tetramer appeared to be specifically localized in grape skin, contrasting with the oligomeric and polymeric procyanidins present in seed, skin, and bunch stem. Moreover, this crown procyanidin tetramer showed promising protective effects against amyloid- induced toxicity.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physical and theoretical chemistry Pharmaceutical science Organic chemistry Odontología Nutrição Molecular medicine Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Economia Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, organic Chemistry, multidisciplinary Chemistry (miscellaneous) Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física Analytical chemistry

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: pere.pons@estudiants.urv.cat

Identificador del autor: 0000-0001-5120-1468

Fecha de alta del registro: 2021-10-10

Volumen de revista: 24

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/1420-3049/24/10/1915

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Molecules. 24 (10):

Referencia de l'ítem segons les normes APA: Zeng, Liming; Pons-Mercade, Pere; Richard, Tristan; Krisa, Stephanie; Teissedre, Pierre-Louis; Jourdes, Michael; (2019). Crown Procyanidin Tetramer: A Procyanidin with an Unusual Cyclic Skeleton with a Potent Protective Effect against Amyloid--Induced Toxicity. Molecules, 24(10), -. DOI: 10.3390/molecules24101915

DOI del artículo: 10.3390/molecules24101915

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Tipo de publicación: Journal Publications