Autor segons l'article: Ejarque, Miriam; Sabadell-Basallote, Joan; Beiroa, Daniel; Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Rodriguez, Maria del Mar; Sabench, Fatima; del Castillo, Daniel; Jimenez, Veronica; Bosch, Fatima; Nogueiras, Ruben; Vendrell, Joan; Fernandez-Veledo, Sonia;
Departament: Ciències Mèdiques Bàsiques Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/s de la URV: Calvo Manso, Enrique / Del Castillo Déjardin, Daniel / Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Sabench Pereferrer, Fàtima / Vendrell Ortega, Juan José
Paraules clau: Teduglutide Short-bowel syndrome Protein-coupled receptor Pharmacology Obesity Obese mice Nervous-system Inflammatory Inflammation In-vivo Glucagon-like peptide-2 Glp‐ Glp-2 Concise guide Anti‐ Anti-inflammatory Adipose tissue 2
Resum: Background and Purpose Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone released in response to nutritional intake that exerts a wide range of effects by activating GLP-2 receptors. In addition to its intestinotrophic effects, GLP-2 also positively influences glucose metabolism under conditions of obesity, but the mechanisms behind this remain unclear. Here, we have investigated the molecular role of the GLP-2/GLP-2 receptor axis in energetic metabolism, focusing on its potential modulatory effects on adipose tissue.
Experimental Approach Physiological measurements (body weight, food intake, locomotor activity, and energy expenditure) and metabolic studies (glucose and insulin tolerance tests) were performed on lean and obese mice treated with the protease-resistant GLP-2 analogue teduglutide.
Key Results Acute but not chronic centrally administered teduglutide decreased food intake and weight-gain. By contrast, chronic activation of peripheral GLP-2 receptors increased body weight-independent glucose tolerance and had anti-inflammatory effects on visceral adipose tissue. Using a gene silencing approach, we found that adipose tissue is necessary for these beneficial effects of teduglutide. Finally, teduglutide regulates the inflammatory state and acts as an anabolic signal in human adipocytes.
Conclusion and Implications Overall, our data identify adipose tissue as a new, clinically relevant, site of action for GLP-2 activity in obesity.
Àrees temàtiques: Saúde coletiva Química Psicología Pharmacology & pharmacy Pharmacology Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Adreça de correu electrònic de l'autor: sonia.fernandez@urv.cat enrique.calvo@urv.cat danieldel.castillo@urv.cat fatima.sabench@urv.cat juanjose.vendrell@urv.cat
Identificador de l'autor: 0000-0003-2906-3788 0000-0003-0456-3102 0000-0001-7024-7824 0000-0002-9262-8756 0000-0002-6994-6115
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.15278
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: British Journal Of Pharmacology. 178 (10): 2131-2145
Referència de l'ítem segons les normes APA: Ejarque, Miriam; Sabadell-Basallote, Joan; Beiroa, Daniel; Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Rodriguez, Maria del Mar; Sabench, Fat (2021). Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function. British Journal Of Pharmacology, 178(10), 2131-2145. DOI: 10.1111/bph.15278
DOI de l'article: 10.1111/bph.15278
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV