Autor según el artículo: Ejarque, Miriam; Sabadell-Basallote, Joan; Beiroa, Daniel; Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Rodriguez, Maria del Mar; Sabench, Fatima; del Castillo, Daniel; Jimenez, Veronica; Bosch, Fatima; Nogueiras, Ruben; Vendrell, Joan; Fernandez-Veledo, Sonia;
Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/es de la URV: Calvo Manso, Enrique / Del Castillo Déjardin, Daniel / Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Sabench Pereferrer, Fàtima / Vendrell Ortega, Juan José
Palabras clave: Teduglutide Short-bowel syndrome Protein-coupled receptor Pharmacology Obesity Obese mice Nervous-system Inflammatory Inflammation In-vivo Glucagon-like peptide-2 Glp‐ Glp-2 Concise guide Anti‐ Anti-inflammatory Adipose tissue 2
Resumen: Background and Purpose Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone released in response to nutritional intake that exerts a wide range of effects by activating GLP-2 receptors. In addition to its intestinotrophic effects, GLP-2 also positively influences glucose metabolism under conditions of obesity, but the mechanisms behind this remain unclear. Here, we have investigated the molecular role of the GLP-2/GLP-2 receptor axis in energetic metabolism, focusing on its potential modulatory effects on adipose tissue.
Experimental Approach Physiological measurements (body weight, food intake, locomotor activity, and energy expenditure) and metabolic studies (glucose and insulin tolerance tests) were performed on lean and obese mice treated with the protease-resistant GLP-2 analogue teduglutide.
Key Results Acute but not chronic centrally administered teduglutide decreased food intake and weight-gain. By contrast, chronic activation of peripheral GLP-2 receptors increased body weight-independent glucose tolerance and had anti-inflammatory effects on visceral adipose tissue. Using a gene silencing approach, we found that adipose tissue is necessary for these beneficial effects of teduglutide. Finally, teduglutide regulates the inflammatory state and acts as an anabolic signal in human adipocytes.
Conclusion and Implications Overall, our data identify adipose tissue as a new, clinically relevant, site of action for GLP-2 activity in obesity.
Áreas temáticas: Saúde coletiva Química Psicología Pharmacology & pharmacy Pharmacology Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Direcció de correo del autor: sonia.fernandez@urv.cat enrique.calvo@urv.cat danieldel.castillo@urv.cat fatima.sabench@urv.cat juanjose.vendrell@urv.cat
Identificador del autor: 0000-0003-2906-3788 0000-0003-0456-3102 0000-0001-7024-7824 0000-0002-9262-8756 0000-0002-6994-6115
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.15278
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: British Journal Of Pharmacology. 178 (10): 2131-2145
Referencia de l'ítem segons les normes APA: Ejarque, Miriam; Sabadell-Basallote, Joan; Beiroa, Daniel; Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Rodriguez, Maria del Mar; Sabench, Fat (2021). Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function. British Journal Of Pharmacology, 178(10), 2131-2145. DOI: 10.1111/bph.15278
DOI del artículo: 10.1111/bph.15278
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications