Articles producció científica> Enginyeria Química

Medical plaster enhancement by coating with Cistus L. extracts within a chitosan matrix: from natural complexity to health care simplicity

  • Dades identificatives

    Identificador: imarina:9148940
    Autors:
    Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini *
    Resum:
    Our investigation was focused on the preparation and characterization of novel plasters based on Carboxymethyl Chitosan derivative (CMC), to be used for the treatment of radiation dermatitis with Biologic Active Compounds (BACs) in a moist wound-healing environment. After performing the extraction and characterization of BACs from Cistus L., we optimized the BACs/CMC solution for subsequent plaster preparation. Then, plasters were prepared by dip-coating with a different number of layers, and we characterized them by Environmental Scanning Electron Microscopy (ESEM), Contact Angle (CA) and release tests in water for 24 h. Taking into account the flexibility of the plasters and the amount of released BACs after 24 h, the sample obtained after two dip-coating steps (2La) appeared promising in regard to comfortable mechanical properties and active principles administration. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test performed on keratinocytes cultured in standard medium shows that cells treated with released extract from 2La start to proliferate, extend cellular viability and form colonies typical for epidermal cells.
  • Altres:

    Autor segons l'article: Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini *
    Departament: Enginyeria Química
    Autor/s de la URV: Giamberini, Marta / Tylkowski, Bartosz
    Paraules clau: Tissue regeneration Scanning electron microscopy Radiation dermatitis Plaster Natural complexity Medical plaster Environmental scanning electron microscopies (esem) Contact angle Coatings Chitosan matrices Chitosan Cellular viability Carboxymethyl chitosan Biomechanics Biologic active compounds Active principles Active compounds
    Resum: Our investigation was focused on the preparation and characterization of novel plasters based on Carboxymethyl Chitosan derivative (CMC), to be used for the treatment of radiation dermatitis with Biologic Active Compounds (BACs) in a moist wound-healing environment. After performing the extraction and characterization of BACs from Cistus L., we optimized the BACs/CMC solution for subsequent plaster preparation. Then, plasters were prepared by dip-coating with a different number of layers, and we characterized them by Environmental Scanning Electron Microscopy (ESEM), Contact Angle (CA) and release tests in water for 24 h. Taking into account the flexibility of the plasters and the amount of released BACs after 24 h, the sample obtained after two dip-coating steps (2La) appeared promising in regard to comfortable mechanical properties and active principles administration. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test performed on keratinocytes cultured in standard medium shows that cells treated with released extract from 2La start to proliferate, extend cellular viability and form colonies typical for epidermal cells.
    Àrees temàtiques: Physics, condensed matter Physics, applied Metallurgy & metallurgical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Condensed matter physics Chemistry, physical
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1996-1944
    Adreça de correu electrònic de l'autor: marta.giamberini@urv.cat bartosz.tylkowski@urv.cat
    Identificador de l'autor: 0000-0001-8278-3552 0000-0002-4163-0178
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/1996-1944/14/3/582
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Materials. 14 (3): 582-13
    Referència de l'ítem segons les normes APA: Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini * (2021). Medical plaster enhancement by coating with Cistus L. extracts within a chitosan matrix: from natural complexity to health care simplicity. Materials, 14(3), 582-13. DOI: 10.3390/ma14030582
    DOI de l'article: 10.3390/ma14030582
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Chemistry, Physical,Condensed Matter Physics,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Metallurgy & Metallurgical Engineering,Physics, Applied,Physics, Condensed Matter
    Tissue regeneration
    Scanning electron microscopy
    Radiation dermatitis
    Plaster
    Natural complexity
    Medical plaster
    Environmental scanning electron microscopies (esem)
    Contact angle
    Coatings
    Chitosan matrices
    Chitosan
    Cellular viability
    Carboxymethyl chitosan
    Biomechanics
    Biologic active compounds
    Active principles
    Active compounds
    Physics, condensed matter
    Physics, applied
    Metallurgy & metallurgical engineering
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    Condensed matter physics
    Chemistry, physical
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