Autor según el artículo: Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini *

Departamento: Enginyeria Química

Autor/es de la URV: Giamberini, Marta / Tylkowski, Bartosz

Palabras clave: Tissue regeneration Scanning electron microscopy Radiation dermatitis Plaster Natural complexity Medical plaster Environmental scanning electron microscopies (esem) Contact angle Coatings Chitosan matrices Chitosan Cellular viability Carboxymethyl chitosan Biomechanics Biologic active compounds Active principles Active compounds

Resumen: Our investigation was focused on the preparation and characterization of novel plasters based on Carboxymethyl Chitosan derivative (CMC), to be used for the treatment of radiation dermatitis with Biologic Active Compounds (BACs) in a moist wound-healing environment. After performing the extraction and characterization of BACs from Cistus L., we optimized the BACs/CMC solution for subsequent plaster preparation. Then, plasters were prepared by dip-coating with a different number of layers, and we characterized them by Environmental Scanning Electron Microscopy (ESEM), Contact Angle (CA) and release tests in water for 24 h. Taking into account the flexibility of the plasters and the amount of released BACs after 24 h, the sample obtained after two dip-coating steps (2La) appeared promising in regard to comfortable mechanical properties and active principles administration. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test performed on keratinocytes cultured in standard medium shows that cells treated with released extract from 2La start to proliferate, extend cellular viability and form colonies typical for epidermal cells.

Áreas temáticas: Physics, condensed matter Physics, applied Metallurgy & metallurgical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Condensed matter physics Chemistry, physical

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1996-1944

Direcció de correo del autor: bartosz.tylkowski@urv.cat marta.giamberini@urv.cat

Identificador del autor: 0000-0002-4163-0178 0000-0001-8278-3552

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/1996-1944/14/3/582

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Materials. 14 (3): 582-13

Referencia de l'ítem segons les normes APA: Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini * (2021). Medical plaster enhancement by coating with Cistus L. extracts within a chitosan matrix: from natural complexity to health care simplicity. Materials, 14(3), 582-13. DOI: 10.3390/ma14030582

DOI del artículo: 10.3390/ma14030582

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications