Articles producció científica> Enginyeria Química

Medical plaster enhancement by coating with Cistus L. extracts within a chitosan matrix: from natural complexity to health care simplicity

  • Identification data

    Identifier: imarina:9148940
    Authors:
    Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini *
    Abstract:
    Our investigation was focused on the preparation and characterization of novel plasters based on Carboxymethyl Chitosan derivative (CMC), to be used for the treatment of radiation dermatitis with Biologic Active Compounds (BACs) in a moist wound-healing environment. After performing the extraction and characterization of BACs from Cistus L., we optimized the BACs/CMC solution for subsequent plaster preparation. Then, plasters were prepared by dip-coating with a different number of layers, and we characterized them by Environmental Scanning Electron Microscopy (ESEM), Contact Angle (CA) and release tests in water for 24 h. Taking into account the flexibility of the plasters and the amount of released BACs after 24 h, the sample obtained after two dip-coating steps (2La) appeared promising in regard to comfortable mechanical properties and active principles administration. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test performed on keratinocytes cultured in standard medium shows that cells treated with released extract from 2La start to proliferate, extend cellular viability and form colonies typical for epidermal cells.
  • Others:

    Author, as appears in the article.: Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini *
    Department: Enginyeria Química
    URV's Author/s: Giamberini, Marta / Tylkowski, Bartosz
    Keywords: Tissue regeneration Scanning electron microscopy Radiation dermatitis Plaster Natural complexity Medical plaster Environmental scanning electron microscopies (esem) Contact angle Coatings Chitosan matrices Chitosan Cellular viability Carboxymethyl chitosan Biomechanics Biologic active compounds Active principles Active compounds
    Abstract: Our investigation was focused on the preparation and characterization of novel plasters based on Carboxymethyl Chitosan derivative (CMC), to be used for the treatment of radiation dermatitis with Biologic Active Compounds (BACs) in a moist wound-healing environment. After performing the extraction and characterization of BACs from Cistus L., we optimized the BACs/CMC solution for subsequent plaster preparation. Then, plasters were prepared by dip-coating with a different number of layers, and we characterized them by Environmental Scanning Electron Microscopy (ESEM), Contact Angle (CA) and release tests in water for 24 h. Taking into account the flexibility of the plasters and the amount of released BACs after 24 h, the sample obtained after two dip-coating steps (2La) appeared promising in regard to comfortable mechanical properties and active principles administration. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test performed on keratinocytes cultured in standard medium shows that cells treated with released extract from 2La start to proliferate, extend cellular viability and form colonies typical for epidermal cells.
    Thematic Areas: Physics, condensed matter Physics, applied Metallurgy & metallurgical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Condensed matter physics Chemistry, physical
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1996-1944
    Author's mail: marta.giamberini@urv.cat bartosz.tylkowski@urv.cat
    Author identifier: 0000-0001-8278-3552 0000-0002-4163-0178
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1996-1944/14/3/582
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Materials. 14 (3): 582-13
    APA: Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini * (2021). Medical plaster enhancement by coating with Cistus L. extracts within a chitosan matrix: from natural complexity to health care simplicity. Materials, 14(3), 582-13. DOI: 10.3390/ma14030582
    Article's DOI: 10.3390/ma14030582
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Chemistry, Physical,Condensed Matter Physics,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Metallurgy & Metallurgical Engineering,Physics, Applied,Physics, Condensed Matter
    Tissue regeneration
    Scanning electron microscopy
    Radiation dermatitis
    Plaster
    Natural complexity
    Medical plaster
    Environmental scanning electron microscopies (esem)
    Contact angle
    Coatings
    Chitosan matrices
    Chitosan
    Cellular viability
    Carboxymethyl chitosan
    Biomechanics
    Biologic active compounds
    Active principles
    Active compounds
    Physics, condensed matter
    Physics, applied
    Metallurgy & metallurgical engineering
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    Condensed matter physics
    Chemistry, physical
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