Autor segons l'article: Pedret A; Catalán Ú; Rubió L; Baiges I; Herrero P; Piñol C; Rodríguez-Calvo R; Canela N; Fernández-Castillejo S; Motilva MJ; Solà R
Departament: Bioquímica i Biotecnologia Medicina i Cirurgia
Autor/s de la URV: BAIGES BLANCO, ISABEL MARIA / Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / HERRERO GIL, POL / Pedret Figuerola, Anna / Rodríguez Calvo, Ricardo / Solà Alberich, Rosa Maria
Paraules clau: Tissues Secoiridoids Proteome Protein-protein interactions Phosphoproteome
Resum: © 2020 American Chemical Society. All rights reserved. Protein functional interactions could explain the biological response of secoiridoids (SECs), main phenolic compounds in virgin olive oil (VOO). The aim was to assess protein-protein interactions (PPIs) of the aorta gap junction alpha-1 (GJA1) and the heart peptidyl-prolyl cis-trans isomerase (FKBP1A), plus the phosphorylated heart proteome, to describe new molecular pathways in the cardiovascular system in rats using nanoliquid chromatography coupled with mass spectrometry. PPIs modified by SECs and associated with GJA1 in aorta rat tissue were calpain, TUBA1A, and HSPB1. Those associated with FKBP1A in rat heart tissue included SUCLG1, HSPE1, and TNNI3. In the heart, SECs modulated the phosphoproteome through the main canonical pathways PI3K/mTOR signaling (AKT1S1 and GAB2) and gap junction signaling (GAB2 and GJA1). PPIs associated with GJA1 and with FKBP1A, the phosphorylation of GAB2, and the dephosphorylation of GJA1 and AKT1S1 in rat tissues are promising protein targets promoting cardiovascular protection to explain the health benefits of VOO.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Planejamento urbano e regional / demografia Odontología Nutrição Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine General chemistry General agricultural and biological sciences Food science & technology Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, applied Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Astronomia / física Agriculture, multidisciplinary Agriculture Agricultural and biological sciences (miscellaneous) Agricultural and biological sciences (all)
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: ursula.catalan@urv.cat ricardo.rodriguez@urv.cat anna.pedret@urv.cat rosa.sola@urv.cat
Identificador de l'autor: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-8359-235X
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
Enllaç font original: https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.0c07164
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Agricultural And Food Chemistry. 69 (5): 1536-1554
Referència de l'ítem segons les normes APA: Pedret A; Catalán Ú; Rubió L; Baiges I; Herrero P; Piñol C; Rodríguez-Calvo R; Canela N; Fernández-Castillejo S; Motilva MJ; Solà R (2021). Phosphoproteomic Analysis and Protein-Protein Interaction of Rat Aorta GJA1 and Rat Heart FKBP1A after Secoiridoid Consumption from Virgin Olive Oil: A Functional Proteomic Approach. Journal Of Agricultural And Food Chemistry, 69(5), 1536-1554. DOI: 10.1021/acs.jafc.0c07164
DOI de l'article: 10.1021/acs.jafc.0c07164
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV