Articles producció científica> Medicina i Cirurgia

Phosphoproteomic Analysis and Protein-Protein Interaction of Rat Aorta GJA1 and Rat Heart FKBP1A after Secoiridoid Consumption from Virgin Olive Oil: A Functional Proteomic Approach

  • Identification data

    Identifier: imarina:9161801
    Handle: http://hdl.handle.net/20.500.11797/imarina9161801
  • Authors:

    Pedret A
    Catalán Ú
    Rubió L
    Baiges I
    Herrero P
    Piñol C
    Rodríguez-Calvo R
    Canela N
    Fernández-Castillejo S
    Motilva MJ
    Solà R
  • Others:

    Author, as appears in the article.: Pedret A; Catalán Ú; Rubió L; Baiges I; Herrero P; Piñol C; Rodríguez-Calvo R; Canela N; Fernández-Castillejo S; Motilva MJ; Solà R
    Department: Bioquímica i Biotecnologia Medicina i Cirurgia
    URV's Author/s: BAIGES BLANCO, ISABEL MARIA / Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / HERRERO GIL, POL / Pedret Figuerola, Anna / Rodríguez Calvo, Ricardo / Solà Alberich, Rosa Maria
    Keywords: Tissues Secoiridoids Proteome Protein-protein interactions Phosphoproteome
    Abstract: © 2020 American Chemical Society. All rights reserved. Protein functional interactions could explain the biological response of secoiridoids (SECs), main phenolic compounds in virgin olive oil (VOO). The aim was to assess protein-protein interactions (PPIs) of the aorta gap junction alpha-1 (GJA1) and the heart peptidyl-prolyl cis-trans isomerase (FKBP1A), plus the phosphorylated heart proteome, to describe new molecular pathways in the cardiovascular system in rats using nanoliquid chromatography coupled with mass spectrometry. PPIs modified by SECs and associated with GJA1 in aorta rat tissue were calpain, TUBA1A, and HSPB1. Those associated with FKBP1A in rat heart tissue included SUCLG1, HSPE1, and TNNI3. In the heart, SECs modulated the phosphoproteome through the main canonical pathways PI3K/mTOR signaling (AKT1S1 and GAB2) and gap junction signaling (GAB2 and GJA1). PPIs associated with GJA1 and with FKBP1A, the phosphorylation of GAB2, and the dephosphorylation of GJA1 and AKT1S1 in rat tissues are promising protein targets promoting cardiovascular protection to explain the health benefits of VOO.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Planejamento urbano e regional / demografia Odontología Nutrição Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine General chemistry General agricultural and biological sciences Food science & technology Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, applied Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Astronomia / física Agriculture, multidisciplinary Agriculture Agricultural and biological sciences (miscellaneous) Agricultural and biological sciences (all)
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: ricardo.rodriguez@urv.cat ursula.catalan@urv.cat anna.pedret@urv.cat rosa.sola@urv.cat
    Author identifier: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-8359-235X
    Record's date: 2023-02-23
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.0c07164
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Agricultural And Food Chemistry. 69 (5): 1536-1554
    APA: Pedret A; Catalán Ú; Rubió L; Baiges I; Herrero P; Piñol C; Rodríguez-Calvo R; Canela N; Fernández-Castillejo S; Motilva MJ; Solà R (2021). Phosphoproteomic Analysis and Protein-Protein Interaction of Rat Aorta GJA1 and Rat Heart FKBP1A after Secoiridoid Consumption from Virgin Olive Oil: A Functional Proteomic Approach. Journal Of Agricultural And Food Chemistry, 69(5), 1536-1554. DOI: 10.1021/acs.jafc.0c07164
    Article's DOI: 10.1021/acs.jafc.0c07164
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Agricultural and Biological Sciences (Miscellaneous),Agriculture,Agriculture, Multidisciplinary,Chemistry (Miscellaneous),Chemistry, Applied,Food Science & Technology
    Tissues
    Secoiridoids
    Proteome
    Protein-protein interactions
    Phosphoproteome
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    General chemistry
    General agricultural and biological sciences
    Food science & technology
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, applied
    Chemistry (miscellaneous)
    Chemistry (all)
    Biotecnología
    Biodiversidade
    Astronomia / física
    Agriculture, multidisciplinary
    Agriculture
    Agricultural and biological sciences (miscellaneous)
    Agricultural and biological sciences (all)
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