Articles producció científica> Bioquímica i Biotecnologia

Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome

  • Dades identificatives

    Identificador: imarina:9173237
    Autors:
    Atzeni, AlessandroGalie, SerenaMuralidharan, JananeeBabio, NancyTinahones, Francisco JoseVioque, JesusCorella, DoloresCastaner, OlgaVidal, JosepMoreno-Indias, IsabelTorres-Collado, LauraFernandez-Carrion, RebecaFito, MontserratOlbeyra, RominaMartinez-Gonzalez, Miguel AngelBullo, MonicaSalas-Salvado, Jordi
    Resum:
    Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.
  • Altres:

    Autor segons l'article: Atzeni, Alessandro; Galie, Serena; Muralidharan, Jananee; Babio, Nancy; Tinahones, Francisco Jose; Vioque, Jesus; Corella, Dolores; Castaner, Olga; Vidal, Josep; Moreno-Indias, Isabel; Torres-Collado, Laura; Fernandez-Carrion, Rebeca; Fito, Montserrat; Olbeyra, Romina; Martinez-Gonzalez, Miguel Angel; Bullo, Monica; Salas-Salvado, Jordi
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Galiè, Serena / Muralidharan, Jananee / Salas Salvadó, Jorge
    Paraules clau: Weight loss Obesity Gut microbiota Clinical trial Bmi 16s sequencing
    Resum: Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.
    Àrees temàtiques: Virology Microbiology (medical) Microbiology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: alessandro.atzeni@urv.cat alessandro.atzeni@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Identificador de l'autor: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2076-2607/9/2/346
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Microorganisms. 9 (2): 1-13
    Referència de l'ítem segons les normes APA: Atzeni, Alessandro; Galie, Serena; Muralidharan, Jananee; Babio, Nancy; Tinahones, Francisco Jose; Vioque, Jesus; Corella, Dolores; Castaner, Olga; Vi (2021). Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome. Microorganisms, 9(2), 1-13. DOI: 10.3390/microorganisms9020346
    DOI de l'article: 10.3390/microorganisms9020346
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Microbiology,Microbiology (Medical),Virology
    Weight loss
    Obesity
    Gut microbiota
    Clinical trial
    Bmi
    16s sequencing
    Virology
    Microbiology (medical)
    Microbiology
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