Ni-Catalyzed Carboxylation of Aziridines en Route to beta-Amino Acids

Identificador:  imarina:9189730

Handle: https://hdl.handle.net/20.500.11797/imarina9189730

Autors:  Davies, J; Janssen-Müller, D; Zimin, DP; Day, CS; Yanagi, T; Elfert, J; Martin, R

Resum:
A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access beta-amino acids, important building blocks with considerable potential as peptidomimetics.