Articles producció científicaQuímica Analítica i Química Orgànica

Ni-Catalyzed Carboxylation of Aziridines en Route to beta-Amino Acids

  • Identification data

    Identifier:  imarina:9189730
    Handle: https://hdl.handle.net/20.500.11797/imarina9189730
    Authors:  Davies, J; Janssen-Müller, D; Zimin, DP; Day, CS; Yanagi, T; Elfert, J; Martin, R
    Abstract:
    A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access beta-amino acids, important building blocks with considerable potential as peptidomimetics.

  • Others:

    Link to the original source: https://pubs.acs.org/doi/10.1021/jacs.1c01916
    APA: Davies, J; Janssen-Müller, D; Zimin, DP; Day, CS; Yanagi, T; Elfert, J; Martin, R (2021). Ni-Catalyzed Carboxylation of Aziridines en Route to beta-Amino Acids. Journal Of The American Chemical Society, 143(13), 4949-4954. DOI: 10.1021/jacs.1c01916
    Paper original source: Journal Of The American Chemical Society. 143 (13): 4949-4954
    Article's DOI: 10.1021/jacs.1c01916
    Journal publication year: 2021-04-07
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2026-05-09
    First page: 4949
    URV's Author/s: Day, Craig
    Department: Química Analítica i Química Orgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Last page: 4954
    Author, as appears in the article.: Davies, J; Janssen-Müller, D; Zimin, DP; Day, CS; Yanagi, T; Elfert, J; Martin, R
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Journal volume: 143
    Thematic Areas: General chemistry, Colloid and surface chemistry, Chemistry, multidisciplinary, Chemistry (miscellaneous), Chemistry (all), Chemistry, Catalysis, Biochemistry, Astronomia / física
    Author's mail: craig.day@estudiants.urv.cat

  • Keywords:

    Unclassified drug
    Regioselectivity
    Reaction time
    Peptidomimetics
    Organic compounds
    Nickel compounds
    Nickel
    Limit of detection
    En-route
    Deprotection reaction
    Cyclization
    Controlled study
    Chemoselectivity
    Chemo-and regioselectivities
    Chemical phenomena
    Catalysis
    Carboxylation
    Carbon dioxide
    Building blockes
    Beta leucine
    Beta homotyrosine
    Beta homotryptophan
    Beta homophenylalanine
    Beta homoleucine
    Beta homoglutamate methyl ester
    Beta homoalanine
    Beta amino acids
    Beta amino acid
    Aziridines
    Aziridine derivative
    Atmospheric pressure
    Article
    Amino acids
    Biochemistry
    Chemistry
    Chemistry (Miscellaneous)
    Multidisciplinary
    Colloid and Surface Chemistry
    General chemistry
    Chemistry (all)
    Astronomia / física

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