Author, as appears in the article.: Davies, Jacob; Janssen-Mueller, Daniel; Zimin, Dmitry P.; Day, Craig S.; Yanagi, Tomoyuki; Elfert, Jonas; Martin, Ruben;

Department: Química Analítica i Química Orgànica

URV's Author/s: Day, Craig

Keywords: Unclassified drug Regioselectivity Reaction time Peptidomimetics Organic compounds Nickel compounds Nickel Limit of detection En-route Deprotection reaction Cyclization Controlled study Chemoselectivity Chemo-and regioselectivities Chemical phenomena Catalysis Carboxylation Carbon dioxide Building blockes Beta leucine Beta homotyrosine Beta homotryptophan Beta homophenylalanine Beta homoleucine Beta homoglutamate methyl ester Beta homoalanine Beta amino acids Beta amino acid Aziridines Aziridine derivative Atmospheric pressure Article Amino acids

Abstract: A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access beta-amino acids, important building blocks with considerable potential as peptidomimetics.

Thematic Areas: Química Materiais Interdisciplinar General chemistry Farmacia Engenharias iv Engenharias iii Engenharias ii Colloid and surface chemistry Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Catalysis Biochemistry Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: craig.day@estudiants.urv.cat

Author identifier: 0000-0002-6931-0280

Last page: 4954

Record's date: 2022-07-24

Journal volume: 143

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://pubs.acs.org/doi/10.1021/jacs.1c01916

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of The American Chemical Society. 143 (13): 4949-4954

APA: Davies, Jacob; Janssen-Mueller, Daniel; Zimin, Dmitry P.; Day, Craig S.; Yanagi, Tomoyuki; Elfert, Jonas; Martin, Ruben; (2021). Ni-Catalyzed Carboxylation of Aziridines en Route to beta-Amino Acids. Journal Of The American Chemical Society, 143(13), 4949-4954. DOI: 10.1021/jacs.1c01916

Article's DOI: 10.1021/jacs.1c01916

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

First page: 4949

Publication Type: Journal Publications