Autor segons l'article: Garcia-Ruiz, Beatriz; de Moura, Manuel Castro; Muntane, Gerard; Martorell, Lourdes; Bosch, Elena; Esteller, Manel; J Canales-Rodriguez, Erick; Pomarol-Clotet, Edith; Jimenez, Esther; Vieta, Eduard; Vilella, Elisabet;
Departament: Medicina i Cirurgia
Autor/s de la URV: Garcia Ruiz, Beatriz / Martorell Bonet, Lourdes / Muntané Medina, Gerard / Vilella Cuadrada, Elisabet
Paraules clau: Vascular endothelial cell Transcription factor Protein fingerprinting Protein expression Priority journal Occipital cortex Myelination Myelin genes Myelin Methylome Methylation Messenger rna Male Human tissue Human cell Human brain Human Glia cell Genome-wide association study Genetic susceptibility Gene expression Female Dna methylation Dna Disease association Discoidin domain receptor 1 Deconvolution Controlled study Clinical article Brain tissue Bipolar disorder Binding site Autopsy Article Adult
Resum: Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.
Àrees temàtiques: Saúde coletiva Medicina veterinaria Medicina ii Medicina i Genetics & heredity Genetics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología Antropologia / arqueologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: gerard.muntane@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat beatriz.garciar@estudiants.urv.cat
Identificador de l'autor: 0000-0003-4999-2197 0000-0002-1887-5919
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.futuremedicine.com/doi/full/10.2217/epi-2021-0006
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Epigenomics. 13 (11): 845-858
Referència de l'ítem segons les normes APA: Garcia-Ruiz, Beatriz; de Moura, Manuel Castro; Muntane, Gerard; Martorell, Lourdes; Bosch, Elena; Esteller, Manel; J Canales-Rodriguez, Erick; Pomarol (2021). DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes. Epigenomics, 13(11), 845-858. DOI: 10.2217/epi-2021-0006
DOI de l'article: 10.2217/epi-2021-0006
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV