Autor según el artículo: Garcia-Ruiz, Beatriz; de Moura, Manuel Castro; Muntane, Gerard; Martorell, Lourdes; Bosch, Elena; Esteller, Manel; J Canales-Rodriguez, Erick; Pomarol-Clotet, Edith; Jimenez, Esther; Vieta, Eduard; Vilella, Elisabet;
Departamento: Medicina i Cirurgia
Autor/es de la URV: Garcia Ruiz, Beatriz / Martorell Bonet, Lourdes / Muntané Medina, Gerard / Vilella Cuadrada, Elisabet
Palabras clave: Vascular endothelial cell Transcription factor Protein fingerprinting Protein expression Priority journal Occipital cortex Myelination Myelin genes Myelin Methylome Methylation Messenger rna Male Human tissue Human cell Human brain Human Glia cell Genome-wide association study Genetic susceptibility Gene expression Female Dna methylation Dna Disease association Discoidin domain receptor 1 Deconvolution Controlled study Clinical article Brain tissue Bipolar disorder Binding site Autopsy Article Adult
Resumen: Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.
Áreas temáticas: Saúde coletiva Medicina veterinaria Medicina ii Medicina i Genetics & heredity Genetics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología Antropologia / arqueologia
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: gerard.muntane@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat beatriz.garciar@estudiants.urv.cat
Identificador del autor: 0000-0003-4999-2197 0000-0002-1887-5919
Fecha de alta del registro: 2024-07-27
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.futuremedicine.com/doi/full/10.2217/epi-2021-0006
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Epigenomics. 13 (11): 845-858
Referencia de l'ítem segons les normes APA: Garcia-Ruiz, Beatriz; de Moura, Manuel Castro; Muntane, Gerard; Martorell, Lourdes; Bosch, Elena; Esteller, Manel; J Canales-Rodriguez, Erick; Pomarol (2021). DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes. Epigenomics, 13(11), 845-858. DOI: 10.2217/epi-2021-0006
DOI del artículo: 10.2217/epi-2021-0006
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV