DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

Identifier:  imarina:9207255

Handle: https://hdl.handle.net/20.500.11797/imarina9207255

Authors:  Garcia-Ruiz, Beatriz; de Moura, Manuel Castro; Muntane, Gerard; Martorell, Lourdes; Bosch, Elena; Esteller, Manel; J Canales-Rodriguez, Erick; Pomarol-Clotet, Edith; Jimenez, Esther; Vieta, Eduard; Vilella, Elisabet

Abstract:
Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.