Author, as appears in the article.: Garcia-Ruiz, Beatriz; de Moura, Manuel Castro; Muntane, Gerard; Martorell, Lourdes; Bosch, Elena; Esteller, Manel; J Canales-Rodriguez, Erick; Pomarol-Clotet, Edith; Jimenez, Esther; Vieta, Eduard; Vilella, Elisabet;
Department: Medicina i Cirurgia
URV's Author/s: Garcia Ruiz, Beatriz / Martorell Bonet, Lourdes / Muntané Medina, Gerard / Vilella Cuadrada, Elisabet
Keywords: Vascular endothelial cell Transcription factor Protein fingerprinting Protein expression Priority journal Occipital cortex Myelination Myelin genes Myelin Methylome Methylation Messenger rna Male Human tissue Human cell Human brain Human Glia cell Genome-wide association study Genetic susceptibility Gene expression Female Dna methylation Dna Disease association Discoidin domain receptor 1 Deconvolution Controlled study Clinical article Brain tissue Bipolar disorder Binding site Autopsy Article Adult
Abstract: Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.
Thematic Areas: Saúde coletiva Medicina veterinaria Medicina ii Medicina i Genetics & heredity Genetics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: gerard.muntane@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat beatriz.garciar@estudiants.urv.cat
Author identifier: 0000-0003-4999-2197 0000-0002-1887-5919
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.futuremedicine.com/doi/full/10.2217/epi-2021-0006
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Epigenomics. 13 (11): 845-858
APA: Garcia-Ruiz, Beatriz; de Moura, Manuel Castro; Muntane, Gerard; Martorell, Lourdes; Bosch, Elena; Esteller, Manel; J Canales-Rodriguez, Erick; Pomarol (2021). DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes. Epigenomics, 13(11), 845-858. DOI: 10.2217/epi-2021-0006
Article's DOI: 10.2217/epi-2021-0006
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV