Autor segons l'article: Masana, Lluis; Correig, Eudald; Ibarretxe, Daiana; Anoro, Eva; Arroyo, Juan Antonio; Jerico, Carlos; Guerrero, Carolina; la Miret, Marcel; Naf, Silvia; Pardo, Anna; Perea, Veronica; Perez-Bernalte, Rosa; Plana, Nuria; Ramirez-Montesinos, Rafael; Royuela, Meritxell; Soler, Cristina; Urquizu-Padilla, Maria; Zamora, Alberto; Pedro-Botet, Juan
Departament: Medicina i Cirurgia
Autor/s de la URV: Correig Fraga, Eudald / Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / Naf Cortés, Silvia Daniela / Plana Gil, Núria / Rodríguez Borjabad, Cèlia
Paraules clau: Triglycerides Triacylglycerol Severity of illness index Middle aged Male Lipids Lipid Humans Human Hospitalization High density lipoprotein cholesterol Fibrin fragment d Fibrin fibrinogen degradation products Fibrin degradation product Ferritins Ferritin Female Etiology Covid-19 Cholesterol, hdl Blood Aged
Resum: Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: daiana.ibarretxe@urv.cat luis.masana@urv.cat eudald.correig@urv.cat celia.rodriguez@urv.cat silviadaniela.naf@urv.cat eudald.correig@urv.cat celia.rodriguez@urv.cat
Identificador de l'autor: 0000-0002-0789-4954 0000-0001-8160-3716 0000-0001-8160-3716
Data d'alta del registre: 2024-08-10
Volum de revista: 11
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.nature.com/articles/s41598-021-86747-5
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Scientific Reports. 11 (1): 7217-
Referència de l'ítem segons les normes APA: Masana, Lluis; Correig, Eudald; Ibarretxe, Daiana; Anoro, Eva; Arroyo, Juan Antonio; Jerico, Carlos; Guerrero, Carolina; la Miret, Marcel; Naf, Silvia (2021). Low HDL and high triglycerides predict COVID-19 severity. Scientific Reports, 11(1), 7217-. DOI: 10.1038/s41598-021-86747-5
DOI de l'article: 10.1038/s41598-021-86747-5
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications