Articles producció científica> Psicologia

Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

  • Dades identificatives

    Identificador: imarina:9216799
    Autors:
    Biosca-Brull, JuditPerez-Fernandez, CristianMora, SantiagoCarrillo, BeatrizPinos, HelenaConejo, Nelida MariaCollado, PalomaArias, Jorge L.Martin-Sanchez, FernandoSanchez-Santed, FernandoColomina, Maria Teresa
    Resum:
    Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.
  • Altres:

    Autor segons l'article: Biosca-Brull, Judit; Perez-Fernandez, Cristian; Mora, Santiago; Carrillo, Beatriz; Pinos, Helena; Conejo, Nelida Maria; Collado, Paloma; Arias, Jorge L.; Martin-Sanchez, Fernando; Sanchez-Santed, Fernando; Colomina, Maria Teresa;
    Departament: Psicologia
    Autor/s de la URV: Biosca Brull, Judit / Colomina Fosch, Maria Teresa
    Paraules clau: Unclassified drug Systematic review Stereotypic behaviors Sociability Rodent models Risk Review Pyrethroid pesticides Pyrethroid Pyrethrins Public health Propoxur Prenatal residential proximity Prenatal exposure delayed effects Prenatal exposure Pregnancy Postnatal exposure Pollution exposure Phosphomedon Phosphinothricin Pesticides Pesticide Organophosphorus pesticide Organophosphate insecticide chlorpyrifos Organophosphate Organochlorine pesticide Organochlorine derivative Organochlorine Organochlo-rine Nonhuman Neonicotinoid Mental health Mancozeb Malathion Incidence Humans Human Gestational exposure Female Developmental-disabilities Cypermethrin Cognitive defect Clinical outcome Chlorpyrifos oxon Chlorpyrifos Child neurodevelopment Carbofuranphenol Carbamic acid Carbamates Behavior disorder Autism spectrum disorder Autism
    Resum: Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental studies Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: judit.biosca@urv.cat judit.biosca@urv.cat mariateresa.colomina@urv.cat
    Identificador de l'autor: 0000-0002-5619-4874
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/1660-4601/18/10/5190
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: International Journal Of Environmental Research And Public Health. 18 (10):
    Referència de l'ítem segons les normes APA: Biosca-Brull, Judit; Perez-Fernandez, Cristian; Mora, Santiago; Carrillo, Beatriz; Pinos, Helena; Conejo, Nelida Maria; Collado, Paloma; Arias, Jorge (2021). Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models. International Journal Of Environmental Research And Public Health, 18(10), -. DOI: 10.3390/ijerph18105190
    DOI de l'article: 10.3390/ijerph18105190
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Environmental Sciences,Health, Toxicology and Mutagenesis,Pollution,Public Health, Environmental and Occupational Health,Public, Environmental & Occupational Health
    Unclassified drug
    Systematic review
    Stereotypic behaviors
    Sociability
    Rodent models
    Risk
    Review
    Pyrethroid pesticides
    Pyrethroid
    Pyrethrins
    Public health
    Propoxur
    Prenatal residential proximity
    Prenatal exposure delayed effects
    Prenatal exposure
    Pregnancy
    Postnatal exposure
    Pollution exposure
    Phosphomedon
    Phosphinothricin
    Pesticides
    Pesticide
    Organophosphorus pesticide
    Organophosphate insecticide chlorpyrifos
    Organophosphate
    Organochlorine pesticide
    Organochlorine derivative
    Organochlorine
    Organochlo-rine
    Nonhuman
    Neonicotinoid
    Mental health
    Mancozeb
    Malathion
    Incidence
    Humans
    Human
    Gestational exposure
    Female
    Developmental-disabilities
    Cypermethrin
    Cognitive defect
    Clinical outcome
    Chlorpyrifos oxon
    Chlorpyrifos
    Child neurodevelopment
    Carbofuranphenol
    Carbamic acid
    Carbamates
    Behavior disorder
    Autism spectrum disorder
    Autism
    Zootecnia / recursos pesqueiros
    Serviço social
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Pollution
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Health, toxicology and mutagenesis
    Geografía
    Geociências
    Farmacia
    Environmental studies
    Environmental sciences
    Ensino
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
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