Autor según el artículo: Biosca-Brull, Judit; Perez-Fernandez, Cristian; Mora, Santiago; Carrillo, Beatriz; Pinos, Helena; Conejo, Nelida Maria; Collado, Paloma; Arias, Jorge L.; Martin-Sanchez, Fernando; Sanchez-Santed, Fernando; Colomina, Maria Teresa;

Departamento: Psicologia

Autor/es de la URV: Biosca Brull, Judit / Colomina Fosch, Maria Teresa

Palabras clave: Unclassified drug Systematic review Stereotypic behaviors Sociability Rodent models Risk Review Pyrethroid pesticides Pyrethroid Pyrethrins Public health Propoxur Prenatal residential proximity Prenatal exposure delayed effects Prenatal exposure Pregnancy Postnatal exposure Pollution exposure Phosphomedon Phosphinothricin Pesticides Pesticide Organophosphorus pesticide Organophosphate insecticide chlorpyrifos Organophosphate Organochlorine pesticide Organochlorine derivative Organochlorine Organochlo-rine Nonhuman Neonicotinoid Mental health Mancozeb Malathion Incidence Humans Human Gestational exposure Female Developmental-disabilities Cypermethrin Cognitive defect Clinical outcome Chlorpyrifos oxon Chlorpyrifos Child neurodevelopment Carbofuranphenol Carbamic acid Carbamates Behavior disorder Autism spectrum disorder Autism

Resumen: Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.

Áreas temáticas: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental studies Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: judit.biosca@urv.cat mariateresa.colomina@urv.cat judit.biosca@urv.cat

Identificador del autor: 0000-0002-5619-4874

Fecha de alta del registro: 2023-08-05

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/1660-4601/18/10/5190

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: International Journal Of Environmental Research And Public Health. 18 (10):

Referencia de l'ítem segons les normes APA: Biosca-Brull, Judit; Perez-Fernandez, Cristian; Mora, Santiago; Carrillo, Beatriz; Pinos, Helena; Conejo, Nelida Maria; Collado, Paloma; Arias, Jorge (2021). Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models. International Journal Of Environmental Research And Public Health, 18(10), -. DOI: 10.3390/ijerph18105190

DOI del artículo: 10.3390/ijerph18105190

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications