Articles producció científicaPsicologia

Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

  • Identification data

    Identifier:  imarina:9216799
    Authors:  Biosca-Brull, Judit; Perez-Fernandez, Cristian; Mora, Santiago; Carrillo, Beatriz; Pinos, Helena; Conejo, Nelida Maria; Collado, Paloma; Arias, Jorge L; Martin-Sanchez, Fernando; Sanchez-Santed, Fernando; Colomina, Maria Teresa
    Abstract:
    Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.
  • Others:

    Link to the original source: https://www.mdpi.com/1660-4601/18/10/5190
    APA: Biosca-Brull, Judit; Perez-Fernandez, Cristian; Mora, Santiago; Carrillo, Beatriz; Pinos, Helena; Conejo, Nelida Maria; Collado, Paloma; Arias, Jorge (2021). Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models. International Journal Of Environmental Research And Public Health, 18(10), 5190-. DOI: 10.3390/ijerph18105190
    Paper original source: International Journal Of Environmental Research And Public Health. 18 (10): 5190-
    Article's DOI: 10.3390/ijerph18105190
    Journal publication year: 2021
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2025-02-18
    URV's Author/s: Biosca Brull, Judit / Colomina Fosch, Maria Teresa
    Department: Psicologia
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Biosca-Brull, Judit; Perez-Fernandez, Cristian; Mora, Santiago; Carrillo, Beatriz; Pinos, Helena; Conejo, Nelida Maria; Collado, Paloma; Arias, Jorge L; Martin-Sanchez, Fernando; Sanchez-Santed, Fernando; Colomina, Maria Teresa
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Zootecnia / recursos pesqueiros, Serviço social, Saúde coletiva, Química, Public, environmental & occupational health, Public health, environmental and occupational health, Psicología, Pollution, Odontología, Nutrição, Medicina iii, Medicina ii, Medicina i, Materiais, Interdisciplinar, Health, toxicology and mutagenesis, Geografía, Geociências, Farmacia, Environmental studies, Environmental sciences, Ensino, Engenharias ii, Engenharias i, Enfermagem, Educação física, Educação, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciências agrárias i, Ciência da computação, Biotecnología, Biodiversidade, Astronomia / física, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: judit.biosca@urv.cat, judit.biosca@urv.cat, mariateresa.colomina@urv.cat
  • Keywords:

    Unclassified drug
    Systematic review
    Stereotypic behaviors
    Sociability
    Rodent models
    Risk
    Review
    Pyrethroid pesticides
    Pyrethroid
    Pyrethrins
    Public health
    Propoxur
    Prenatal residential proximity
    Prenatal exposure delayed effects
    Prenatal exposure
    Pregnancy
    Postnatal exposure
    Pollution exposure
    Phosphomedon
    Phosphinothricin
    Pesticides
    Pesticide
    Organophosphorus pesticide
    Organophosphate insecticide chlorpyrifos
    Organophosphate
    Organochlorine pesticide
    Organochlorine derivative
    Organochlorine
    Organochlo-rine
    Nonhuman
    Neonicotinoid
    Mental health
    Mancozeb
    Malathion
    Incidence
    Humans
    Human
    Gestational exposure
    Female
    Developmental-disabilities
    Cypermethrin
    Cognitive defect
    Clinical outcome
    Chlorpyrifos oxon
    Chlorpyrifos
    Child neurodevelopment
    Carbofuranphenol
    Carbamic acid
    Carbamates
    Behavior disorder
    Autism spectrum disorder
    Autism
    Environmental Sciences
    Health
    Toxicology and Mutagenesis
    Pollution
    Environmental and Occupational Health
    Public
    Environmental & Occupational Health
    Zootecnia / recursos pesqueiros
    Serviço social
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Environmental studies
    Ensino
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Administração pública e de empresas
    ciências contábeis e turismo
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