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Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis

  • Dades identificatives

    Identificador: imarina:9231550
    Handle: https://hdl.handle.net/20.500.11797/imarina9231550
    Autors:
    Barca-Hernando, MariaMunoz-Martin, Andres J.Rios-Herranz, EduardoGarcia-Escobar, IgnacioBeato, CarmenFont, CarmeOncala-Sibajas, EstefaniaRevuelta-Rodriguez, AlfonsoAreses, Maria CarmenRivas-Jimenez, VictorBallaz-Quincoces, AitorMoreno-Santos, Maria AngelesLopez-Saez, Juan-BoscoGallego-Gallego, IriaElias-Hernandez, TeresaAsensio-Cruz, Maria IsabelChasco-Eguilaz, LeyreGarcia-Gonzalez, GonzaloEstevez-Garcia, PurificacionMarin-Barrera, LuciaOtero-Candelera, RemediosLopez-Ruz, SergioLima-Alvarez, JorgeSanchez-Diaz, Jose MariaReal-Dominguez, MacarenaBorrego-Delgado, Maria CarmenMarin-Romero, SamiraJara-Palomares, Luis
    Resum:
    Simple SummaryThe impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients.Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minima

  • Altres:

    Autor segons l'article: Barca-Hernando, Maria; Munoz-Martin, Andres J.; Rios-Herranz, Eduardo; Garcia-Escobar, Ignacio; Beato, Carmen; Font, Carme; Oncala-Sibajas, Estefania; Revuelta-Rodriguez, Alfonso; Areses, Maria Carmen; Rivas-Jimenez, Victor; Ballaz-Quincoces, Aitor; Moreno-Santos, Maria Angeles; Lopez-Saez, Juan-Bosco; Gallego-Gallego, Iria; Elias-Hernandez, Teresa; Asensio-Cruz, Maria Isabel; Chasco-Eguilaz, Leyre; Garcia-Gonzalez, Gonzalo; Estevez-Garcia, Purificacion; Marin-Barrera, Lucia; Otero-Candelera, Remedios; Lopez-Ruz, Sergio; Lima-Alvarez, Jorge; Sanchez-Diaz, Jose Maria; Real-Dominguez, Macarena; Borrego-Delgado, Maria Carmen; Marin-Romero, Samira; Jara-Palomares, Luis;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: PORRAS LEDANTES, JOSE ANTONIO
    Paraules clau: Anaemia Chemotherapy Double-blind Eortc qlq-c30 Epoetin-alpha Fatigue Functional assessment Lung-cancer Neoplasm Outcomes Prevalence Quality of life Symptoms
    Resum: Simple SummaryThe impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients.Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minimally important differences in global health status according to the EORTC QLQ-C30 questionnaire (case vs. controls: 45.6 vs. 58%, respectively; mean difference: -12.4, p < 0.001). Regarding symptoms, cancer patients with anemia had more pronounced symptoms in six out of nine scales in comparison with those without anemia. In conclusion, cancer patients with anemia had a worse QoL both clinically and statistically.
    Àrees temàtiques: Cancer research Medicina iii Oncology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: joseantonio.porras@urv.cat
    Identificador de l'autor: 0000-0001-6418-1822 0000-0002-2265-1221
    Data d'alta del registre: 2021-11-21
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2072-6694/13/11/2517
    Referència a l'article segons font original: Cancers. 13 (11):
    Referència de l'ítem segons les normes APA: Barca-Hernando, Maria; Munoz-Martin, Andres J.; Rios-Herranz, Eduardo; Garcia-Escobar, Ignacio; Beato, Carmen; Font, Carme; Oncala-Sibajas, Estefania; (2021). Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis. Cancers, 13(11), -. DOI: 10.3390/cancers13112517
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.3390/cancers13112517
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Cancer Research,Oncology
    Anaemia
    Chemotherapy
    Double-blind
    Eortc qlq-c30
    Epoetin-alpha
    Fatigue
    Functional assessment
    Lung-cancer
    Neoplasm
    Outcomes
    Prevalence
    Quality of life
    Symptoms
    Cancer research
    Medicina iii
    Oncology

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