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Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis

  • Datos identificativos

    Identificador: imarina:9231550
    Handle: https://hdl.handle.net/20.500.11797/imarina9231550
    Autores:
    Barca-Hernando, MariaMunoz-Martin, Andres J.Rios-Herranz, EduardoGarcia-Escobar, IgnacioBeato, CarmenFont, CarmeOncala-Sibajas, EstefaniaRevuelta-Rodriguez, AlfonsoAreses, Maria CarmenRivas-Jimenez, VictorBallaz-Quincoces, AitorMoreno-Santos, Maria AngelesLopez-Saez, Juan-BoscoGallego-Gallego, IriaElias-Hernandez, TeresaAsensio-Cruz, Maria IsabelChasco-Eguilaz, LeyreGarcia-Gonzalez, GonzaloEstevez-Garcia, PurificacionMarin-Barrera, LuciaOtero-Candelera, RemediosLopez-Ruz, SergioLima-Alvarez, JorgeSanchez-Diaz, Jose MariaReal-Dominguez, MacarenaBorrego-Delgado, Maria CarmenMarin-Romero, SamiraJara-Palomares, Luis
    Resumen:
    Simple SummaryThe impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients.Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minima

  • Otros:

    Autor según el artículo: Barca-Hernando, Maria; Munoz-Martin, Andres J.; Rios-Herranz, Eduardo; Garcia-Escobar, Ignacio; Beato, Carmen; Font, Carme; Oncala-Sibajas, Estefania; Revuelta-Rodriguez, Alfonso; Areses, Maria Carmen; Rivas-Jimenez, Victor; Ballaz-Quincoces, Aitor; Moreno-Santos, Maria Angeles; Lopez-Saez, Juan-Bosco; Gallego-Gallego, Iria; Elias-Hernandez, Teresa; Asensio-Cruz, Maria Isabel; Chasco-Eguilaz, Leyre; Garcia-Gonzalez, Gonzalo; Estevez-Garcia, Purificacion; Marin-Barrera, Lucia; Otero-Candelera, Remedios; Lopez-Ruz, Sergio; Lima-Alvarez, Jorge; Sanchez-Diaz, Jose Maria; Real-Dominguez, Macarena; Borrego-Delgado, Maria Carmen; Marin-Romero, Samira; Jara-Palomares, Luis;
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: PORRAS LEDANTES, JOSE ANTONIO
    Palabras clave: Anaemia Chemotherapy Double-blind Eortc qlq-c30 Epoetin-alpha Fatigue Functional assessment Lung-cancer Neoplasm Outcomes Prevalence Quality of life Symptoms
    Resumen: Simple SummaryThe impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients.Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minimally important differences in global health status according to the EORTC QLQ-C30 questionnaire (case vs. controls: 45.6 vs. 58%, respectively; mean difference: -12.4, p < 0.001). Regarding symptoms, cancer patients with anemia had more pronounced symptoms in six out of nine scales in comparison with those without anemia. In conclusion, cancer patients with anemia had a worse QoL both clinically and statistically.
    Áreas temáticas: Cancer research Medicina iii Oncology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: joseantonio.porras@urv.cat
    Identificador del autor: 0000-0001-6418-1822 0000-0002-2265-1221
    Fecha de alta del registro: 2021-11-21
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2072-6694/13/11/2517
    Referencia al articulo segun fuente origial: Cancers. 13 (11):
    Referencia de l'ítem segons les normes APA: Barca-Hernando, Maria; Munoz-Martin, Andres J.; Rios-Herranz, Eduardo; Garcia-Escobar, Ignacio; Beato, Carmen; Font, Carme; Oncala-Sibajas, Estefania; (2021). Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis. Cancers, 13(11), -. DOI: 10.3390/cancers13112517
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3390/cancers13112517
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Cancer Research,Oncology
    Anaemia
    Chemotherapy
    Double-blind
    Eortc qlq-c30
    Epoetin-alpha
    Fatigue
    Functional assessment
    Lung-cancer
    Neoplasm
    Outcomes
    Prevalence
    Quality of life
    Symptoms
    Cancer research
    Medicina iii
    Oncology

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