Autor segons l'article: Hernandez-Baixauli J; Puigbò P; Abasolo N; Palacios-Jordan H; Foguet-Romero E; Suñol D; Galofré M; Caimari A; Baselga-Escudero L; Del Bas JM; Mulero M
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: ABASOLO ZABALO, NEREA / BASELGA ESCUDERO, LAURA / Del Bas Prior, José María / Mulero Abellán, Miguel
Paraules clau: Unpredictable mild stress Microbiome Metabolome Energy disruption Early stress Chronic unpredictable mild stress Biomarker Animal model proteomics model microbiome metabolome genetics energy disruption depression chronic unpredictable mild stress biomarkers biomarker anxiety animal model
Resum: Stress disorders have dramatically increased in recent decades becoming the most prevalent psychiatric disorder in the United States and Europe. However, the diagnosis of stress disorders is currently based on symptom checklist and psychological questionnaires, thus making the identification of candidate biomarkers necessary to gain better insights into this pathology and its related metabolic alterations. Regarding the identification of potential biomarkers, omic profiling and metabolic footprint arise as promising approaches to recognize early biochemical changes in such disease and provide opportunities for the development of integrative candidate biomarkers. Here, we studied plasma and urine metabolites together with metagenomics in a 3 days Chronic Unpredictable Mild Stress (3d CUMS) animal approach that aims to focus on the early stress period of a well-established depression model. The multi-omics integration showed a profile composed by a signature of eight plasma metabolites, six urine metabolites and five microbes. Specifically, threonic acid, malic acid, alpha-ketoglutarate, succinic acid and cholesterol were proposed as key metabolites that could serve as key potential biomarkers in plasma metabolome of early stages of stress. Such findings targeted the threonic acid metabolism and the tricarboxylic acid (TCA) cycle as important pathways in early stress. Additionally, an increase in opportunistic microbes as virus of the Herpesvirales was observed in the microbiota as an effect of the primary stress stages. Our results provide an experimental biochemical characterization of the early stage of CUMS accompanied by a subsequent omic profiling and a metabolic footprinting that provide potential candidate biomarkers. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: josepm.delbas@urv.cat miquel.mulero@urv.cat
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/22/23/12931
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 22 (23):
Referència de l'ítem segons les normes APA: Hernandez-Baixauli J; Puigbò P; Abasolo N; Palacios-Jordan H; Foguet-Romero E; Suñol D; Galofré M; Caimari A; Baselga-Escudero L; Del Bas JM; Mulero M (2021). Alterations in metabolome and microbiome associated with an early stress stage in male wistar rats: A multi-omics approach. International Journal Of Molecular Sciences, 22(23), -. DOI: 10.3390/ijms222312931
DOI de l'article: 10.3390/ijms222312931
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV