Autor según el artículo: Hernandez-Baixauli J; Puigbò P; Abasolo N; Palacios-Jordan H; Foguet-Romero E; Suñol D; Galofré M; Caimari A; Baselga-Escudero L; Del Bas JM; Mulero M
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: ABASOLO ZABALO, NEREA / BASELGA ESCUDERO, LAURA / Del Bas Prior, José María / Mulero Abellán, Miguel
Palabras clave: Unpredictable mild stress Microbiome Metabolome Energy disruption Early stress Chronic unpredictable mild stress Biomarker Animal model proteomics model microbiome metabolome genetics energy disruption depression chronic unpredictable mild stress biomarkers biomarker anxiety animal model
Resumen: Stress disorders have dramatically increased in recent decades becoming the most prevalent psychiatric disorder in the United States and Europe. However, the diagnosis of stress disorders is currently based on symptom checklist and psychological questionnaires, thus making the identification of candidate biomarkers necessary to gain better insights into this pathology and its related metabolic alterations. Regarding the identification of potential biomarkers, omic profiling and metabolic footprint arise as promising approaches to recognize early biochemical changes in such disease and provide opportunities for the development of integrative candidate biomarkers. Here, we studied plasma and urine metabolites together with metagenomics in a 3 days Chronic Unpredictable Mild Stress (3d CUMS) animal approach that aims to focus on the early stress period of a well-established depression model. The multi-omics integration showed a profile composed by a signature of eight plasma metabolites, six urine metabolites and five microbes. Specifically, threonic acid, malic acid, alpha-ketoglutarate, succinic acid and cholesterol were proposed as key metabolites that could serve as key potential biomarkers in plasma metabolome of early stages of stress. Such findings targeted the threonic acid metabolism and the tricarboxylic acid (TCA) cycle as important pathways in early stress. Additionally, an increase in opportunistic microbes as virus of the Herpesvirales was observed in the microbiota as an effect of the primary stress stages. Our results provide an experimental biochemical characterization of the early stage of CUMS accompanied by a subsequent omic profiling and a metabolic footprinting that provide potential candidate biomarkers. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: josepm.delbas@urv.cat miquel.mulero@urv.cat
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/1422-0067/22/23/12931
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 22 (23):
Referencia de l'ítem segons les normes APA: Hernandez-Baixauli J; Puigbò P; Abasolo N; Palacios-Jordan H; Foguet-Romero E; Suñol D; Galofré M; Caimari A; Baselga-Escudero L; Del Bas JM; Mulero M (2021). Alterations in metabolome and microbiome associated with an early stress stage in male wistar rats: A multi-omics approach. International Journal Of Molecular Sciences, 22(23), -. DOI: 10.3390/ijms222312931
DOI del artículo: 10.3390/ijms222312931
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV