Articles producció científica> Química Analítica i Química Orgànica

Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins

  • Dades identificatives

    Identificador: imarina:9247880
    Autors:
    Cobo IMatheu MICastillón SDavis BGBoutureira O
    Resum:
    Methods that site-selectively attach multivalent carbohydrate moieties to proteins can be used to generate homogeneous glycodendriproteins as synthetic functional mimics of glycoproteins. Here, we study aspects of the scope and limitations of some common bioconjugation techniques that can give access to well-defined glycodendriproteins. A diverse reactive platform was designed via use of thiol-Michael-type additions, thiol-ene reactions, and Cu(I)-mediated azide-alkyne cycloadditions from recombinant proteins containing the non-canonical amino acids dehydroalanine, homoallylglycine, homopropargylglycine, and azidohomoalanine.© 2022 Wiley-VCH GmbH.
  • Altres:

    Autor segons l'article: Cobo I; Matheu MI; Castillón S; Davis BG; Boutureira O
    Departament: Química Analítica i Química Orgànica
    Autor/s de la URV: Boutureira Martín, Omar / Castillón Miranda, Sergio / Matheu Malpartida, María Isabel
    Paraules clau: Protein modifications Glycoproteins Glycoprotein-synthesis Dendrimers Bioorthogonal reactions Bioconjugations strategy protein modifications protein ligands lectin glycosylation glycoproteins glycomimetics dendrimers dehydroalanine cysteine bioorthogonal reactions adhesion
    Resum: Methods that site-selectively attach multivalent carbohydrate moieties to proteins can be used to generate homogeneous glycodendriproteins as synthetic functional mimics of glycoproteins. Here, we study aspects of the scope and limitations of some common bioconjugation techniques that can give access to well-defined glycodendriproteins. A diverse reactive platform was designed via use of thiol-Michael-type additions, thiol-ene reactions, and Cu(I)-mediated azide-alkyne cycloadditions from recombinant proteins containing the non-canonical amino acids dehydroalanine, homoallylglycine, homopropargylglycine, and azidohomoalanine.© 2022 Wiley-VCH GmbH.
    Àrees temàtiques: Química Organic chemistry Molecular medicine Molecular biology Medicina ii Materiais Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências ambientais Chemistry, medicinal Biotecnología Biochemistry & molecular biology Biochemistry Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: omar.boutureira@urv.cat maribel.matheu@urv.cat sergio.castillon@urv.cat
    Identificador de l'autor: 0000-0002-0768-8309 0000-0001-5216-9260 0000-0002-0690-7549
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200020
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Chembiochem. 23 (10): e202200020-
    Referència de l'ítem segons les normes APA: Cobo I; Matheu MI; Castillón S; Davis BG; Boutureira O (2022). Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins. Chembiochem, 23(10), e202200020-. DOI: 10.1002/cbic.202200020
    DOI de l'article: 10.1002/cbic.202200020
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry,Biochemistry & Molecular Biology,Chemistry, Medicinal,Molecular Biology,Molecular Medicine,Organic Chemistry
    Protein modifications
    Glycoproteins
    Glycoprotein-synthesis
    Dendrimers
    Bioorthogonal reactions
    Bioconjugations
    strategy
    protein modifications
    protein
    ligands
    lectin
    glycosylation
    glycoproteins
    glycomimetics
    dendrimers
    dehydroalanine
    cysteine
    bioorthogonal reactions
    adhesion
    Química
    Organic chemistry
    Molecular medicine
    Molecular biology
    Medicina ii
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Chemistry, medicinal
    Biotecnología
    Biochemistry & molecular biology
    Biochemistry
    Astronomia / física
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