Articles producció científica> Química Analítica i Química Orgànica

Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins

  • Identification data

    Identifier: imarina:9247880
  • Authors:

    Cobo I
    Matheu MI
    Castillón S
    Davis BG
    Boutureira O
  • Others:

    Author, as appears in the article.: Cobo I; Matheu MI; Castillón S; Davis BG; Boutureira O
    Department: Química Analítica i Química Orgànica
    URV's Author/s: Boutureira Martín, Omar / Castillón Miranda, Sergio / Matheu Malpartida, María Isabel
    Keywords: Protein modifications Glycoproteins Glycoprotein-synthesis Dendrimers Bioorthogonal reactions Bioconjugations strategy protein modifications protein ligands lectin glycosylation glycoproteins glycomimetics dendrimers dehydroalanine cysteine bioorthogonal reactions adhesion
    Abstract: Methods that site-selectively attach multivalent carbohydrate moieties to proteins can be used to generate homogeneous glycodendriproteins as synthetic functional mimics of glycoproteins. Here, we study aspects of the scope and limitations of some common bioconjugation techniques that can give access to well-defined glycodendriproteins. A diverse reactive platform was designed via use of thiol-Michael-type additions, thiol-ene reactions, and Cu(I)-mediated azide-alkyne cycloadditions from recombinant proteins containing the non-canonical amino acids dehydroalanine, homoallylglycine, homopropargylglycine, and azidohomoalanine.© 2022 Wiley-VCH GmbH.
    Thematic Areas: Química Organic chemistry Molecular medicine Molecular biology Medicina ii Materiais Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências ambientais Chemistry, medicinal Biotecnología Biochemistry & molecular biology Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: omar.boutureira@urv.cat maribel.matheu@urv.cat sergio.castillon@urv.cat
    Author identifier: 0000-0002-0768-8309 0000-0001-5216-9260 0000-0002-0690-7549
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200020
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Chembiochem. 23 (10): e202200020-
    APA: Cobo I; Matheu MI; Castillón S; Davis BG; Boutureira O (2022). Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins. Chembiochem, 23(10), e202200020-. DOI: 10.1002/cbic.202200020
    Article's DOI: 10.1002/cbic.202200020
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Chemistry, Medicinal,Molecular Biology,Molecular Medicine,Organic Chemistry
    Protein modifications
    Glycoproteins
    Glycoprotein-synthesis
    Dendrimers
    Bioorthogonal reactions
    Bioconjugations
    strategy
    protein modifications
    protein
    ligands
    lectin
    glycosylation
    glycoproteins
    glycomimetics
    dendrimers
    dehydroalanine
    cysteine
    bioorthogonal reactions
    adhesion
    Química
    Organic chemistry
    Molecular medicine
    Molecular biology
    Medicina ii
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Chemistry, medicinal
    Biotecnología
    Biochemistry & molecular biology
    Biochemistry
    Astronomia / física
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