Autor según el artículo: Cobo, Isidro; Matheu, M Isabel; Castillon, Sergio; Davis, Benjamin G; Boutureira, Omar
Departamento: Química Analítica i Química Orgànica
Autor/es de la URV: Boutureira Martín, Omar / Castillón Miranda, Sergio / Matheu Malpartida, María Isabel
Palabras clave: Sulfhydryl compounds Recombinant proteins Protein modifications Glycoproteins Glycoprotein-synthesis Dendrimers Cycloaddition reaction Bioorthogonal reactions Bioconjugations Azides Amino acids strategy protein modifications protein ligands lectin glycosylation glycoproteins glycomimetics dendrimers dehydroalanine cysteine bioorthogonal reactions adhesion
Resumen: Methods that site-selectively attach multivalent carbohydrate moieties to proteins can be used to generate homogeneous glycodendriproteins as synthetic functional mimics of glycoproteins. Here, we study aspects of the scope and limitations of some common bioconjugation techniques that can give access to well-defined glycodendriproteins. A diverse reactive platform was designed via use of thiol-Michael-type additions, thiol-ene reactions, and Cu(I)-mediated azide-alkyne cycloadditions from recombinant proteins containing the non-canonical amino acids dehydroalanine, homoallylglycine, homopropargylglycine, and azidohomoalanine.© 2022 Wiley-VCH GmbH.
Áreas temáticas: Química Organic chemistry Molecular medicine Molecular biology Medicina ii Materiais Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências ambientais Chemistry, medicinal Biotecnología Biochemistry & molecular biology Biochemistry Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: omar.boutureira@urv.cat maribel.matheu@urv.cat sergio.castillon@urv.cat
Identificador del autor: 0000-0002-0768-8309 0000-0001-5216-9260 0000-0002-0690-7549
Fecha de alta del registro: 2024-11-30
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Chembiochem. 23 (10): e202200020-
Referencia de l'ítem segons les normes APA: Cobo, Isidro; Matheu, M Isabel; Castillon, Sergio; Davis, Benjamin G; Boutureira, Omar (2022). Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins. Chembiochem, 23(10), e202200020-. DOI: 10.1002/cbic.202200020
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV