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Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters

  • Dades identificatives

    Identificador: imarina:9258940
    Autors:
    Jiang LSarró PTeo WJLlop JSuero MG
    Resum:
    Herein we describe the first construction of fluorinated tertiary stereocenters based on an alkene C(sp(2))-C(sp(2)) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.
  • Altres:

    Autor segons l'article: Jiang L; Sarró P; Teo WJ; Llop J; Suero MG
    Departament: Química Analítica i Química Orgànica
    Autor/s de la URV: Sarró Grané, Pau
    Paraules clau: Phase-transfer catalysis Nonsteroidal antiinflammatory drugs Enantioselective fluorination Decarboxylative fluorination Combination Chemistry Asymmetric fluorination Alkyl fluorides Activation Acids
    Resum: Herein we describe the first construction of fluorinated tertiary stereocenters based on an alkene C(sp(2))-C(sp(2)) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.
    Àrees temàtiques: Química Materiais Interdisciplinar General chemistry Farmacia Ciências biológicas iii Ciências biológicas i Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: pau.sarro@estudiants.urv.cat
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://pubs.rsc.org/en/content/articlelanding/2022/sc/d2sc00968d
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Chemical Science.
    Referència de l'ítem segons les normes APA: Jiang L; Sarró P; Teo WJ; Llop J; Suero MG (2022). Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters. Chemical Science, (), -. DOI: 10.1039/d2sc00968d
    DOI de l'article: 10.1039/d2sc00968d
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    Phase-transfer catalysis
    Nonsteroidal antiinflammatory drugs
    Enantioselective fluorination
    Decarboxylative fluorination
    Combination
    Chemistry
    Asymmetric fluorination
    Alkyl fluorides
    Activation
    Acids
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Farmacia
    Ciências biológicas iii
    Ciências biológicas i
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Astronomia / física
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