Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters

Identificador:  imarina:9258940

Handle: https://hdl.handle.net/20.500.11797/imarina9258940

Autores:  Jiang L; Sarró P; Teo WJ; Llop J; Suero MG

Resumen:
Herein we describe the first construction of fluorinated tertiary stereocenters based on an alkene C(sp(2))-C(sp(2)) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.