Autor segons l'article: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; Lehrer, Eduardo; Jordana, Marta; Ramirez-Ruiz, Rosa Delia; Costa, Jose Miguel; Oleaga, Laura; Bernal-Sprekelsen, Manuel
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Avilés Jurado, Francisco Javier
Paraules clau: Transoral laser microsurgery; Tolms; Survival; Squamous-cell carcinoma; Squamous cell carcinoma; Retrospective studies; Prognosis; Paraglottic space; Organ preservation; Neoplasm staging; Microsurgery; Margins; Locally advanced; Laser therapy; Larynx compartment; Laryngectomy; Laryngeal neoplasms; Laryngeal cancer; Humans; Head; Glottis; Disease-free survival; Chemotherapy
Resum: Background To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.
Àrees temàtiques: Surgery; Saúde coletiva; Otorhinolaryngology; Odontología; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; General medicine; Farmacia; Engenharias iv; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: franciscojavier.aviles@urv.cat
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/10.1002/hed.26878
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 43 (12): 3832-3842
Referència de l'ítem segons les normes APA: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; L (2021). Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck, 43(12), 3832-3842. DOI: 10.1002/hed.26878
DOI de l'article: 10.1002/hed.26878
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV