Autor segons l'article: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; Lehrer, Eduardo; Jordana, Marta; Ramirez-Ruiz, Rosa Delia; Costa, Jose Miguel; Oleaga, Laura; Bernal-Sprekelsen, Manuel
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Avilés Jurado, Francisco Javier
Paraules clau: Transoral laser microsurgery Tolms Survival Squamous-cell carcinoma Squamous cell carcinoma Retrospective studies Prognosis Paraglottic space Organ preservation Neoplasm staging Microsurgery Margins Locally advanced Laser therapy Larynx compartment Laryngectomy Laryngeal neoplasms Laryngeal cancer Humans Head Glottis Disease-free survival Chemotherapy
Resum: Background To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.
Àrees temàtiques: Surgery Saúde coletiva Otorhinolaryngology Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: franciscojavier.aviles@urv.cat
Identificador de l'autor: 0000-0001-5560-8097
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/10.1002/hed.26878
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 43 (12): 3832-3842
Referència de l'ítem segons les normes APA: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; L (2021). Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck, 43(12), 3832-3842. DOI: 10.1002/hed.26878
DOI de l'article: 10.1002/hed.26878
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV