Author, as appears in the article.: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; Lehrer, Eduardo; Jordana, Marta; Ramirez-Ruiz, Rosa Delia; Costa, Jose Miguel; Oleaga, Laura; Bernal-Sprekelsen, Manuel;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Avilés Jurado, Francisco Javier
Keywords: Chemotherapy Head Laryngeal cancer Larynx compartment Locally advanced Margins Organ preservation Paraglottic space Squamous cell carcinoma Squamous-cell carcinoma Survival Tolms Transoral laser microsurgery
Abstract: Background To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.
Thematic Areas: Biotecnología Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Engenharias iv Farmacia General medicine Interdisciplinar Medicina i Medicina ii Medicina iii Odontología Otorhinolaryngology Saúde coletiva Surgery
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: franciscojavier.aviles@urv.cat
Author identifier: 0000-0001-5560-8097
Record's date: 2024-03-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/hed.26878
Papper original source: Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 43 (12): 3832-3842
APA: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; L (2021). Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck, 43(12), 3832-3842. DOI: 10.1002/hed.26878
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1002/hed.26878
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV