Articles producció científica> Ciències Mèdiques Bàsiques

Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments

  • Identification data

    Identifier: imarina:9261212
    Authors:
    Vilaseca, IsabelAviles-Jurado, Francesc XavierValduvieco, IzaskunBerenguer, JoanGrau, Juan JoseBaste, NeusMuxi, AfricaCastillo, PaolaLehrer, EduardoJordana, MartaRamirez-Ruiz, Rosa DeliaCosta, Jose MiguelOleaga, LauraBernal-Sprekelsen, Manuel
    Abstract:
    Background To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.
  • Others:

    Author, as appears in the article.: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; Lehrer, Eduardo; Jordana, Marta; Ramirez-Ruiz, Rosa Delia; Costa, Jose Miguel; Oleaga, Laura; Bernal-Sprekelsen, Manuel
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Avilés Jurado, Francisco Javier
    Keywords: Transoral laser microsurgery Tolms Survival Squamous-cell carcinoma Squamous cell carcinoma Retrospective studies Prognosis Paraglottic space Organ preservation Neoplasm staging Microsurgery Margins Locally advanced Laser therapy Larynx compartment Laryngectomy Laryngeal neoplasms Laryngeal cancer Humans Head Glottis Disease-free survival Chemotherapy
    Abstract: Background To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.
    Thematic Areas: Surgery Saúde coletiva Otorhinolaryngology Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: franciscojavier.aviles@urv.cat
    Author identifier: 0000-0001-5560-8097
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/hed.26878
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 43 (12): 3832-3842
    APA: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; L (2021). Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck, 43(12), 3832-3842. DOI: 10.1002/hed.26878
    Article's DOI: 10.1002/hed.26878
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Otorhinolaryngology,Surgery
    Transoral laser microsurgery
    Tolms
    Survival
    Squamous-cell carcinoma
    Squamous cell carcinoma
    Retrospective studies
    Prognosis
    Paraglottic space
    Organ preservation
    Neoplasm staging
    Microsurgery
    Margins
    Locally advanced
    Laser therapy
    Larynx compartment
    Laryngectomy
    Laryngeal neoplasms
    Laryngeal cancer
    Humans
    Head
    Glottis
    Disease-free survival
    Chemotherapy
    Surgery
    Saúde coletiva
    Otorhinolaryngology
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar