Articles producció científica> Ciències Mèdiques Bàsiques

Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments

  • Datos identificativos

    Identificador: imarina:9261212
    Autores:
    Vilaseca, IsabelAviles-Jurado, Francesc XavierValduvieco, IzaskunBerenguer, JoanGrau, Juan JoseBaste, NeusMuxi, AfricaCastillo, PaolaLehrer, EduardoJordana, MartaRamirez-Ruiz, Rosa DeliaCosta, Jose MiguelOleaga, LauraBernal-Sprekelsen, Manuel
    Resumen:
    Background To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.
  • Otros:

    Autor según el artículo: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; Lehrer, Eduardo; Jordana, Marta; Ramirez-Ruiz, Rosa Delia; Costa, Jose Miguel; Oleaga, Laura; Bernal-Sprekelsen, Manuel
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Avilés Jurado, Francisco Javier
    Palabras clave: Transoral laser microsurgery Tolms Survival Squamous-cell carcinoma Squamous cell carcinoma Retrospective studies Prognosis Paraglottic space Organ preservation Neoplasm staging Microsurgery Margins Locally advanced Laser therapy Larynx compartment Laryngectomy Laryngeal neoplasms Laryngeal cancer Humans Head Glottis Disease-free survival Chemotherapy
    Resumen: Background To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.
    Áreas temáticas: Surgery Saúde coletiva Otorhinolaryngology Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: franciscojavier.aviles@urv.cat
    Identificador del autor: 0000-0001-5560-8097
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/hed.26878
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck. 43 (12): 3832-3842
    Referencia de l'ítem segons les normes APA: Vilaseca, Isabel; Aviles-Jurado, Francesc Xavier; Valduvieco, Izaskun; Berenguer, Joan; Grau, Juan Jose; Baste, Neus; Muxi, Africa; Castillo, Paola; L (2021). Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck, 43(12), 3832-3842. DOI: 10.1002/hed.26878
    DOI del artículo: 10.1002/hed.26878
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Otorhinolaryngology,Surgery
    Transoral laser microsurgery
    Tolms
    Survival
    Squamous-cell carcinoma
    Squamous cell carcinoma
    Retrospective studies
    Prognosis
    Paraglottic space
    Organ preservation
    Neoplasm staging
    Microsurgery
    Margins
    Locally advanced
    Laser therapy
    Larynx compartment
    Laryngectomy
    Laryngeal neoplasms
    Laryngeal cancer
    Humans
    Head
    Glottis
    Disease-free survival
    Chemotherapy
    Surgery
    Saúde coletiva
    Otorhinolaryngology
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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