Articles producció científica> Medicina i Cirurgia

Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity

  • Dades identificatives

    Identificador: imarina:9262319
    Autors:
    Algaba-Chueca FMaymó-Masip EBallesteros MGuarque AMajali-Martínez AFreixes OAmigó NFernández-Veledo SVendrell JMegía A
    Resum:
    Abnormal lipid metabolism is associated with gestational diabetes mellitus (GDM) and is observed in neonates with abnormal fetal growth. However, the underlying specific changes in the lipoprotein profile remain poorly understood. Thus, in the present study we used a novel nuclear magnetic resonance (NMR)-based approach to profile the umbilical cord serum lipoproteins. Two-dimensional diffusion-ordered 1H-NMR spectroscopy showed that size, lipid content, number and concentration of particles within their subclasses were similar between offspring born to control (n = 74) and GDM (n = 62) mothers. Subsequent data stratification according to newborn birth-weight categories, i.e., small (n = 39), appropriate (n = 50) or large (n = 49) for gestational age (SGA, AGA and LGA, respectively), showed an interaction between GDM and birth-weight categories for inter-mediate-density lipoproteins (IDL)-cholesterol content and IDL-and low-density lipoproteins (LDL)-triglyceride content, and the number of medium very low-density lipoproteins (VLDL) and LDL particles specifically in AGA neonates. Moreover, in a 2-year follow-up study, we observed that small LDL particles were independently associated with offspring obesity at 2 years (n = 103). Collectively, our data demonstrate that GDM disturbs triglyceride and cholesterol lipoprotein content across birth-weight categories, with AGA neonates born to GDM mothers displaying a profile more similar to that of adults with dyslipidemia. Furthermore, an altered fetal lipoprotein pattern was associated with the development of obesity at 2 years.
  • Altres:

    Autor segons l'article: Algaba-Chueca F; Maymó-Masip E; Ballesteros M; Guarque A; Majali-Martínez A; Freixes O; Amigó N; Fernández-Veledo S; Vendrell J; Megía A
    Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/s de la URV: Ballesteros Pérez, Monica / Fernandez Veledo, Sonia / Guarque Rus, Albert / Maymo Masip, Elsa / Megía Colet, Ana / Vendrell Ortega, Juan José
    Paraules clau: Obesity Lipoprotein profile High-density-lipoprotein Gestational diabetes Fetal blood Birth-weight pregnancy obesity newborns metabolism mellitus maternal lipids lipoprotein profile intima-media thickness growth gestational diabetes fetal blood fetal cholesterol
    Resum: Abnormal lipid metabolism is associated with gestational diabetes mellitus (GDM) and is observed in neonates with abnormal fetal growth. However, the underlying specific changes in the lipoprotein profile remain poorly understood. Thus, in the present study we used a novel nuclear magnetic resonance (NMR)-based approach to profile the umbilical cord serum lipoproteins. Two-dimensional diffusion-ordered 1H-NMR spectroscopy showed that size, lipid content, number and concentration of particles within their subclasses were similar between offspring born to control (n = 74) and GDM (n = 62) mothers. Subsequent data stratification according to newborn birth-weight categories, i.e., small (n = 39), appropriate (n = 50) or large (n = 49) for gestational age (SGA, AGA and LGA, respectively), showed an interaction between GDM and birth-weight categories for inter-mediate-density lipoproteins (IDL)-cholesterol content and IDL-and low-density lipoproteins (LDL)-triglyceride content, and the number of medium very low-density lipoproteins (VLDL) and LDL particles specifically in AGA neonates. Moreover, in a 2-year follow-up study, we observed that small LDL particles were independently associated with offspring obesity at 2 years (n = 103). Collectively, our data demonstrate that GDM disturbs triglyceride and cholesterol lipoprotein content across birth-weight categories, with AGA neonates born to GDM mothers displaying a profile more similar to that of adults with dyslipidemia. Furthermore, an altered fetal lipoprotein pattern was associated with the development of obesity at 2 years.
    Àrees temàtiques: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: albert.guarque@urv.cat elsa.maymo@urv.cat monica.ballesteros@urv.cat sonia.fernandez@urv.cat ana.megia@urv.cat juanjose.vendrell@urv.cat
    Identificador de l'autor: 0000-0002-9133-3120 0000-0003-2906-3788 0000-0002-5101-9452 0000-0002-6994-6115
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2227-9059/10/5/1033
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Biomedicines. 10 (5):
    Referència de l'ítem segons les normes APA: Algaba-Chueca F; Maymó-Masip E; Ballesteros M; Guarque A; Majali-Martínez A; Freixes O; Amigó N; Fernández-Veledo S; Vendrell J; Megía A (2022). Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity. Biomedicines, 10(5), -. DOI: 10.3390/biomedicines10051033
    DOI de l'article: 10.3390/biomedicines10051033
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry & Molecular Biology,Biochemistry, Genetics and Molecular Biology (Miscellaneous),Medicine (Miscellaneous),Medicine, Research & Experimental,Pharmacology & Pharmacy
    Obesity
    Lipoprotein profile
    High-density-lipoprotein
    Gestational diabetes
    Fetal blood
    Birth-weight
    pregnancy
    obesity
    newborns
    metabolism
    mellitus
    maternal lipids
    lipoprotein profile
    intima-media thickness
    growth
    gestational diabetes
    fetal blood
    fetal
    cholesterol
    Pharmacology & pharmacy
    Medicine, research & experimental
    Medicine (miscellaneous)
    General biochemistry,genetics and molecular biology
    Ciencias sociales
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Biochemistry & molecular biology
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