Author, as appears in the article.: Algaba-Chueca, Francisco; Maymo-Masip, Elsa; Ballesteros, Monica; Guarque, Albert; Majali-Martinez, Alejandro; Freixes, Olga; Amigo, Nuria; Fernandez-Veledo, Sonia; Vendrell, Joan; Megia, Ana
Department: Medicina i Cirurgia; Ciències Mèdiques Bàsiques
URV's Author/s: Ballesteros Pérez, Monica / Fernandez Veledo, Sonia / Guarque Rus, Albert / Maymo Masip, Elsa / Megía Colet, Ana / Vendrell Ortega, Juan José
Keywords: Obesity; Lipoprotein profile; High-density-lipoprotein; Gestational diabetes; Fetal blood; Birth-weight; pregnancy; obesity; newborns; metabolism; mellitus; maternal lipids; lipoprotein profile; intima-media thickness; growth; gestational diabetes; fetal blood; fetal; cholesterol
Abstract: Abnormal lipid metabolism is associated with gestational diabetes mellitus (GDM) and is observed in neonates with abnormal fetal growth. However, the underlying specific changes in the lipoprotein profile remain poorly understood. Thus, in the present study we used a novel nuclear magnetic resonance (NMR)-based approach to profile the umbilical cord serum lipoproteins. Two-dimensional diffusion-ordered 1H-NMR spectroscopy showed that size, lipid content, number and concentration of particles within their subclasses were similar between offspring born to control (n = 74) and GDM (n = 62) mothers. Subsequent data stratification according to newborn birth-weight categories, i.e., small (n = 39), appropriate (n = 50) or large (n = 49) for gestational age (SGA, AGA and LGA, respectively), showed an interaction between GDM and birth-weight categories for inter-mediate-density lipoproteins (IDL)-cholesterol content and IDL-and low-density lipoproteins (LDL)-triglyceride content, and the number of medium very low-density lipoproteins (VLDL) and LDL particles specifically in AGA neonates. Moreover, in a 2-year follow-up study, we observed that small LDL particles were independently associated with offspring obesity at 2 years (n = 103). Collectively, our data demonstrate that GDM disturbs triglyceride and cholesterol lipoprotein content across birth-weight categories, with AGA neonates born to GDM mothers displaying a profile more similar to that of adults with dyslipidemia. Furthermore, an altered fetal lipoprotein pattern was associated with the development of obesity at 2 years.
Thematic Areas: Pharmacology & pharmacy; Medicine, research & experimental; Medicine (miscellaneous); General biochemistry,genetics and molecular biology; Ciencias sociales; Biochemistry, genetics and molecular biology (miscellaneous); Biochemistry, genetics and molecular biology (all); Biochemistry & molecular biology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: albert.guarque@urv.cat; elsa.maymo@urv.cat; monica.ballesteros@urv.cat; sonia.fernandez@urv.cat; ana.megia@urv.cat; jvortega@iispv.cat
Record's date: 2025-02-01
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2227-9059/10/5/1033
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Biomedicines. 10 (5): 1033-
APA: Algaba-Chueca, Francisco; Maymo-Masip, Elsa; Ballesteros, Monica; Guarque, Albert; Majali-Martinez, Alejandro; Freixes, Olga; Amigo, Nuria; Fernandez- (2022). Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity. Biomedicines, 10(5), 1033-. DOI: 10.3390/biomedicines10051033
Article's DOI: 10.3390/biomedicines10051033
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV