Autor según el artículo: Algaba-Chueca F; Maymó-Masip E; Ballesteros M; Guarque A; Majali-Martínez A; Freixes O; Amigó N; Fernández-Veledo S; Vendrell J; Megía A
Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: Ballesteros Pérez, Monica / Fernandez Veledo, Sonia / Guarque Rus, Albert / Maymo Masip, Elsa / Megía Colet, Ana / Vendrell Ortega, Juan José
Palabras clave: Obesity Lipoprotein profile High-density-lipoprotein Gestational diabetes Fetal blood Birth-weight pregnancy obesity newborns metabolism mellitus maternal lipids lipoprotein profile intima-media thickness growth gestational diabetes fetal blood fetal cholesterol
Resumen: Abnormal lipid metabolism is associated with gestational diabetes mellitus (GDM) and is observed in neonates with abnormal fetal growth. However, the underlying specific changes in the lipoprotein profile remain poorly understood. Thus, in the present study we used a novel nuclear magnetic resonance (NMR)-based approach to profile the umbilical cord serum lipoproteins. Two-dimensional diffusion-ordered 1H-NMR spectroscopy showed that size, lipid content, number and concentration of particles within their subclasses were similar between offspring born to control (n = 74) and GDM (n = 62) mothers. Subsequent data stratification according to newborn birth-weight categories, i.e., small (n = 39), appropriate (n = 50) or large (n = 49) for gestational age (SGA, AGA and LGA, respectively), showed an interaction between GDM and birth-weight categories for inter-mediate-density lipoproteins (IDL)-cholesterol content and IDL-and low-density lipoproteins (LDL)-triglyceride content, and the number of medium very low-density lipoproteins (VLDL) and LDL particles specifically in AGA neonates. Moreover, in a 2-year follow-up study, we observed that small LDL particles were independently associated with offspring obesity at 2 years (n = 103). Collectively, our data demonstrate that GDM disturbs triglyceride and cholesterol lipoprotein content across birth-weight categories, with AGA neonates born to GDM mothers displaying a profile more similar to that of adults with dyslipidemia. Furthermore, an altered fetal lipoprotein pattern was associated with the development of obesity at 2 years.
Áreas temáticas: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: albert.guarque@urv.cat elsa.maymo@urv.cat monica.ballesteros@urv.cat sonia.fernandez@urv.cat ana.megia@urv.cat juanjose.vendrell@urv.cat
Identificador del autor: 0000-0002-9133-3120 0000-0003-2906-3788 0000-0002-5101-9452 0000-0002-6994-6115
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2227-9059/10/5/1033
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Biomedicines. 10 (5):
Referencia de l'ítem segons les normes APA: Algaba-Chueca F; Maymó-Masip E; Ballesteros M; Guarque A; Majali-Martínez A; Freixes O; Amigó N; Fernández-Veledo S; Vendrell J; Megía A (2022). Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity. Biomedicines, 10(5), -. DOI: 10.3390/biomedicines10051033
DOI del artículo: 10.3390/biomedicines10051033
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications