Autor segons l'article: Barrot, J; Real, J; Vlacho, B; Romero-Aroca, P; Simo, R; Mauricio, D; Mata-Cases, M; Castelblanco, E; Mundet-Tuduri, X; Franch-Nadal, J
Departament: Medicina i Cirurgia
Autor/s de la URV: Romero Aroca, Pedro
Paraules clau: Stroke Risk-factor Real word data analyses Primary healthcare Prevalence Mortality Mellitus Macrovascular complication Heart-disease Epidemiology Diabetic retinopathy Atherosclerosis Association
Resum: This study aimed to evaluate the predictive value of diabetic retinopathy (DR) and its stages with the incidence of major cardiovascular events and all-cause mortality in type 2 diabetes mellitus (T2DM) persons in our large primary healthcare database from Catalonia (Spain). A retrospective cohort study with pseudo-anonymized routinely collected health data from SIDIAP was conducted from 2008 to 2016. We calculated incidence rates of major cardiovascular events [coronary heart disease (CHD), stroke, or both-macrovascular events] and all-cause mortality for subjects with and without DR and for different stages of DR. The proportional hazards regression analysis was done to assess the probability of occurrence between DR and the study events. About 22,402 T2DM subjects with DR were identified in the database and 196,983 subjects without DR. During the follow-up period among the subjects with DR, we observed the highest incidence of all-cause mortally. In the second place were the macrovascular events among the subjects with DR. In the multivariable analysis, fully adjusted for DR, sex, age, body mass index (BMI), tobacco, duration of T2DM, an antiplatelet or antihypertensive drug, and HbA1c, we observed that subjects with any stage of DR had higher risks for all of the study events, except for stroke. We observed the highest probability of all-cause death events (adjusted hazard ratios, AHRs: 1.34, 95% CI: 1.28; 1.41). In conclusion, our results show that DR is related to CHD, macrovascular events, and all-cause mortality among persons with T2DM.
Àrees temàtiques: Oncology Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina ii General medicine Farmacia Ciências biológicas i Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: pedro.romero@urv.cat
Identificador de l'autor: 0000-0002-7061-8987
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fmed.2022.945245/full
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Frontiers Of Medicine. 9
Referència de l'ítem segons les normes APA: Barrot, J; Real, J; Vlacho, B; Romero-Aroca, P; Simo, R; Mauricio, D; Mata-Cases, M; Castelblanco, E; Mundet-Tuduri, X; Franch-Nadal, J (2022). Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes. Frontiers Of Medicine, 9(), -. DOI: 10.3389/fmed.2022.945245
DOI de l'article: 10.3389/fmed.2022.945245
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications