Articles producció científica> Medicina i Cirurgia

Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes

  • Datos identificativos

    Identificador: imarina:9281564
    Autores:
    Barrot, JReal, JVlacho, BRomero-Aroca, PSimo, RMauricio, DMata-Cases, MCastelblanco, EMundet-Tuduri, XFranch-Nadal, J
    Resumen:
    This study aimed to evaluate the predictive value of diabetic retinopathy (DR) and its stages with the incidence of major cardiovascular events and all-cause mortality in type 2 diabetes mellitus (T2DM) persons in our large primary healthcare database from Catalonia (Spain). A retrospective cohort study with pseudo-anonymized routinely collected health data from SIDIAP was conducted from 2008 to 2016. We calculated incidence rates of major cardiovascular events [coronary heart disease (CHD), stroke, or both-macrovascular events] and all-cause mortality for subjects with and without DR and for different stages of DR. The proportional hazards regression analysis was done to assess the probability of occurrence between DR and the study events. About 22,402 T2DM subjects with DR were identified in the database and 196,983 subjects without DR. During the follow-up period among the subjects with DR, we observed the highest incidence of all-cause mortally. In the second place were the macrovascular events among the subjects with DR. In the multivariable analysis, fully adjusted for DR, sex, age, body mass index (BMI), tobacco, duration of T2DM, an antiplatelet or antihypertensive drug, and HbA1c, we observed that subjects with any stage of DR had higher risks for all of the study events, except for stroke. We observed the highest probability of all-cause death events (adjusted hazard ratios, AHRs: 1.34, 95% CI: 1.28; 1.41). In conclusion, our results show that DR is related to CHD, macrovascular events, and all-cause mortality among persons with T2DM.
  • Otros:

    Autor según el artículo: Barrot, J; Real, J; Vlacho, B; Romero-Aroca, P; Simo, R; Mauricio, D; Mata-Cases, M; Castelblanco, E; Mundet-Tuduri, X; Franch-Nadal, J
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Romero Aroca, Pedro
    Palabras clave: Stroke Risk-factor Real word data analyses Primary healthcare Prevalence Mortality Mellitus Macrovascular complication Heart-disease Epidemiology Diabetic retinopathy Atherosclerosis Association
    Resumen: This study aimed to evaluate the predictive value of diabetic retinopathy (DR) and its stages with the incidence of major cardiovascular events and all-cause mortality in type 2 diabetes mellitus (T2DM) persons in our large primary healthcare database from Catalonia (Spain). A retrospective cohort study with pseudo-anonymized routinely collected health data from SIDIAP was conducted from 2008 to 2016. We calculated incidence rates of major cardiovascular events [coronary heart disease (CHD), stroke, or both-macrovascular events] and all-cause mortality for subjects with and without DR and for different stages of DR. The proportional hazards regression analysis was done to assess the probability of occurrence between DR and the study events. About 22,402 T2DM subjects with DR were identified in the database and 196,983 subjects without DR. During the follow-up period among the subjects with DR, we observed the highest incidence of all-cause mortally. In the second place were the macrovascular events among the subjects with DR. In the multivariable analysis, fully adjusted for DR, sex, age, body mass index (BMI), tobacco, duration of T2DM, an antiplatelet or antihypertensive drug, and HbA1c, we observed that subjects with any stage of DR had higher risks for all of the study events, except for stroke. We observed the highest probability of all-cause death events (adjusted hazard ratios, AHRs: 1.34, 95% CI: 1.28; 1.41). In conclusion, our results show that DR is related to CHD, macrovascular events, and all-cause mortality among persons with T2DM.
    Áreas temáticas: Oncology Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina ii General medicine Farmacia Ciências biológicas i Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: pedro.romero@urv.cat
    Identificador del autor: 0000-0002-7061-8987
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fmed.2022.945245/full
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Frontiers Of Medicine. 9
    Referencia de l'ítem segons les normes APA: Barrot, J; Real, J; Vlacho, B; Romero-Aroca, P; Simo, R; Mauricio, D; Mata-Cases, M; Castelblanco, E; Mundet-Tuduri, X; Franch-Nadal, J (2022). Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes. Frontiers Of Medicine, 9(), -. DOI: 10.3389/fmed.2022.945245
    DOI del artículo: 10.3389/fmed.2022.945245
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental,Oncology
    Stroke
    Risk-factor
    Real word data analyses
    Primary healthcare
    Prevalence
    Mortality
    Mellitus
    Macrovascular complication
    Heart-disease
    Epidemiology
    Diabetic retinopathy
    Atherosclerosis
    Association
    Oncology
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina ii
    General medicine
    Farmacia
    Ciências biológicas i
    Biodiversidade
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