Autor segons l'article: Canyelles, Marina; Perez, Antonio; Junza, Alexandra; Minambres, Inka; Yanes, Oscar; Sarda, Helena; Rotllan, Noemi; Julve, Josep; Luis Sanchez-Quesada, Jose; Tondo, Mireia; Escola-Gil, Joan Carles; Blanco-Vaca, Francisco
Departament: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/s de la URV: Junza Martínez, Alexandra / Yanes Torrado, Óscar
Paraules clau: Γ-butyrobetaine Type 2 diabetes Trimethylamine-n-oxide Trimethylamine n-oxide Risk Obesity Mortality Microbial-metabolism Liquid chromatography–mass spectrometry Liquid chromatography-mass spectrometry Glycemic control Gamma-butyrobetaine Choline Carnitine Butyrobetaine
Resum: High circulating concentrations of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) are significantly associated with the risk of obesity and type 2 diabetes (T2D). We aimed at evaluating the impact of glycemic control and bariatric surgery on circulating concentrations of TMAO and its microbiota-dependent intermediate, gamma-butyrobetaine (gamma BB), in newly diagnosed T2D patients and morbidly obese subjects following a within-subject design. Based on HbA1c concentrations, T2D patients achieved glycemic control. However, the plasma TMAO and gamma BB concentrations were significantly increased, without changes in estimated glomerular filtration rate. Bariatric surgery was very effective in reducing weight in obese subjects. Nevertheless, the surgery reduced plasma gamma BB concentrations without affecting TMAO concentrations and the estimated glomerular filtration rate. Considering these results, an additional experiment was carried out in male C57BL/6J mice fed a Western-type diet for twelve weeks. Neither diet-induced obesity nor insulin resistance were associated with circulating TMAO and gamma BB concentrations in these genetically defined mice strains. Our findings do not support that glycemic control or bariatric surgery improve the circulating concentrations of TMAO in newly diagnosed T2D and morbidly obese patients.
Àrees temàtiques: Medicine, general & internal Internal medicine Clinical biochemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: oscar.yanes@urv.cat alexandra.junza@urv.cat
Identificador de l'autor: 0000-0003-3695-7157 0000-0001-7205-0419
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2075-4418/12/11/2783
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Diagnostics. 12 (11): 2783-
Referència de l'ítem segons les normes APA: Canyelles, Marina; Perez, Antonio; Junza, Alexandra; Minambres, Inka; Yanes, Oscar; Sarda, Helena; Rotllan, Noemi; Julve, Josep; Luis Sanchez-Quesada, (2022). Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. Diagnostics, 12(11), 2783-. DOI: 10.3390/diagnostics12112783
DOI de l'article: 10.3390/diagnostics12112783
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications