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Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese

  • Datos identificativos

    Identificador: imarina:9287705
    Autores:
    Canyelles, MarinaPerez, AntonioJunza, AlexandraMinambres, InkaYanes, OscarSarda, HelenaRotllan, NoemiJulve, JosepLuis Sanchez-Quesada, JoseTondo, MireiaEscola-Gil, Joan CarlesBlanco-Vaca, Francisco
    Resumen:
    High circulating concentrations of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) are significantly associated with the risk of obesity and type 2 diabetes (T2D). We aimed at evaluating the impact of glycemic control and bariatric surgery on circulating concentrations of TMAO and its microbiota-dependent intermediate, gamma-butyrobetaine (gamma BB), in newly diagnosed T2D patients and morbidly obese subjects following a within-subject design. Based on HbA1c concentrations, T2D patients achieved glycemic control. However, the plasma TMAO and gamma BB concentrations were significantly increased, without changes in estimated glomerular filtration rate. Bariatric surgery was very effective in reducing weight in obese subjects. Nevertheless, the surgery reduced plasma gamma BB concentrations without affecting TMAO concentrations and the estimated glomerular filtration rate. Considering these results, an additional experiment was carried out in male C57BL/6J mice fed a Western-type diet for twelve weeks. Neither diet-induced obesity nor insulin resistance were associated with circulating TMAO and gamma BB concentrations in these genetically defined mice strains. Our findings do not support that glycemic control or bariatric surgery improve the circulating concentrations of TMAO in newly diagnosed T2D and morbidly obese patients.
  • Otros:

    Autor según el artículo: Canyelles, Marina; Perez, Antonio; Junza, Alexandra; Minambres, Inka; Yanes, Oscar; Sarda, Helena; Rotllan, Noemi; Julve, Josep; Luis Sanchez-Quesada, Jose; Tondo, Mireia; Escola-Gil, Joan Carles; Blanco-Vaca, Francisco
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: Junza Martínez, Alexandra / Yanes Torrado, Óscar
    Palabras clave: Γ-butyrobetaine Type 2 diabetes Trimethylamine-n-oxide Trimethylamine n-oxide Risk Obesity Mortality Microbial-metabolism Liquid chromatography–mass spectrometry Liquid chromatography-mass spectrometry Glycemic control Gamma-butyrobetaine Choline Carnitine Butyrobetaine
    Resumen: High circulating concentrations of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) are significantly associated with the risk of obesity and type 2 diabetes (T2D). We aimed at evaluating the impact of glycemic control and bariatric surgery on circulating concentrations of TMAO and its microbiota-dependent intermediate, gamma-butyrobetaine (gamma BB), in newly diagnosed T2D patients and morbidly obese subjects following a within-subject design. Based on HbA1c concentrations, T2D patients achieved glycemic control. However, the plasma TMAO and gamma BB concentrations were significantly increased, without changes in estimated glomerular filtration rate. Bariatric surgery was very effective in reducing weight in obese subjects. Nevertheless, the surgery reduced plasma gamma BB concentrations without affecting TMAO concentrations and the estimated glomerular filtration rate. Considering these results, an additional experiment was carried out in male C57BL/6J mice fed a Western-type diet for twelve weeks. Neither diet-induced obesity nor insulin resistance were associated with circulating TMAO and gamma BB concentrations in these genetically defined mice strains. Our findings do not support that glycemic control or bariatric surgery improve the circulating concentrations of TMAO in newly diagnosed T2D and morbidly obese patients.
    Áreas temáticas: Medicine, general & internal Internal medicine Clinical biochemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: oscar.yanes@urv.cat alexandra.junza@urv.cat
    Identificador del autor: 0000-0003-3695-7157 0000-0001-7205-0419
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2075-4418/12/11/2783
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Diagnostics. 12 (11): 2783-
    Referencia de l'ítem segons les normes APA: Canyelles, Marina; Perez, Antonio; Junza, Alexandra; Minambres, Inka; Yanes, Oscar; Sarda, Helena; Rotllan, Noemi; Julve, Josep; Luis Sanchez-Quesada, (2022). Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. Diagnostics, 12(11), 2783-. DOI: 10.3390/diagnostics12112783
    DOI del artículo: 10.3390/diagnostics12112783
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Clinical Biochemistry,Medicine, General & Internal
    Γ-butyrobetaine
    Type 2 diabetes
    Trimethylamine-n-oxide
    Trimethylamine n-oxide
    Risk
    Obesity
    Mortality
    Microbial-metabolism
    Liquid chromatography–mass spectrometry
    Liquid chromatography-mass spectrometry
    Glycemic control
    Gamma-butyrobetaine
    Choline
    Carnitine
    Butyrobetaine
    Medicine, general & internal
    Internal medicine
    Clinical biochemistry
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