Autor segons l'article: Arreaza-Gil, Veronica; Escobar-Martinez, Ivan; Mulero, Miquel; Muguerza, Begona; Suarez, Manuel; Arola-Arnal, Anna; Torres-Fuentes, Cristina
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Alkhoury, Nadine / Arola Arnal, Anna / Arreaza Gil, Verónica / Muguerza Marquínez, Maria Begoña / Mulero Abellán, Miguel / Suárez Recio, Manuel / Torres Fuentes, Cristina
Paraules clau: Tandem mass spectrometry; Seasonal rhythms; Rats, inbred f344; Rats; Proanthocyanidins; Polyphenols; Photoperiod; Obesity; Gut microbiota; Gspe; Grape seed proanthocyanidins; Grape seed extract; Gastrointestinal microbiome; Diet; Biological availability; Bioavailability; Animals; xenohormesis; seasonal rhythms; polyphenols; plasma kinetics; obesity; metabolic syndrome; healthy; gut microbiota; gspe; flavanols; flavan-3-ols; blood-pressure; 3-hydroxyphenylacetic acid
Resum: Polyphenols health effects on obesity are mainly attributed to their metabolites generated after their gastrointestinal digestion, in which gut microbiota plays an important role. Moreover, gut microbiota composition and polyphenols bioavailability are influenced by differences in day light length (photoperiod). Thus, this study evaluated if a grape seed proanthocyanidins extract (GSPE) bioavailability is influenced by different photoperiod exposure via gut microbiota modulation in an obesogenic context.Cafeteria diet-induced obese Fischer 344 rats were housed under different photoperiod conditions (6, 12 or 18 h of light per day) during 9 weeks and administered with GSPE (25 mg/kg) or GSPE and an antibiotic cocktail (ABX) for the last 4 weeks. Serum GSPE-derived metabolites were quantified by HPLC-MS/MS.A higher bioavailability was observed under L6 compared to L18. Individual metabolites, especially those from the gut microbiota, were affected by photoperiods. ABX treatment altered these photoperiod-mediated changes. Therefore, these results suggest that gut microbiota plays a key role in the photoperiod effects on GSPE bioavailability in obese rats. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
Àrees temàtiques: Saúde coletiva; Química; Nutrição; Medicina veterinaria; Medicina ii; Medicina i; Interdisciplinar; Food science & technology; Food science; Farmacia; Educação física; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biotechnology; Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; veronica.arreaza@urv.cat; veronica.arreaza@urv.cat; veronica.arreaza@urv.cat; manuel.suarez@urv.cat; miquel.mulero@urv.cat; anna.arola@urv.cat; begona.muguerza@urv.cat; cristina.torres@urv.cat
Data d'alta del registre: 2025-01-08
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.202200600
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Molecular Nutrition & Food Research. 67 (9): e2200600-e2200600
Referència de l'ítem segons les normes APA: Arreaza-Gil, Veronica; Escobar-Martinez, Ivan; Mulero, Miquel; Muguerza, Begona; Suarez, Manuel; Arola-Arnal, Anna; Torres-Fuentes, Cristina (2023). Gut Microbiota Influences the Photoperiod Effects on Proanthocyanidins Bioavailability in Diet-Induced Obese Rats. Molecular Nutrition & Food Research, 67(9), e2200600-e2200600. DOI: 10.1002/mnfr.202200600
DOI de l'article: 10.1002/mnfr.202200600
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV